Gendrel D, Richard-Lenoble D, Massamba M B, Picaud A, Francoual C, Blot P
Département de Pédiatrie, Hopital St Vincent de Paul, Paris, France.
J Trop Pediatr. 1990 Dec;36(6):279-82. doi: 10.1093/tropej/36.6.279.
The aim of the study was to compare the placental transfer of tetanus toxoid antibodies (TTAB) and total IgG in Africa, where we had previously demonstrated a lack of transmission from mother to the newborn of measles antibodies. Two series of mother-child pairs, 45 in Paris and 134 in Libreville, Gabon, Central Africa, were measured after full-term pregnancies and normal deliveries. Means of ratios of cord/mother concentrations for TT AB and IgG were, respectively, 2.52 and 1.28 in Paris and 0.98 and 0.82 in Gabon. In 11 pairs from Libreville no TT AB were found in mother and cord blood, but in four other African newborns (3 per cent), the mother transmitted TT AB which were lower than protective level against tetanus. Other data (negative correlation between mother IgG and cord/mother ratio of corresponding TT AB concentrations, and better transmission of TT AB in the low range of maternal IgG) indicate that the limitation of active placental transfer of antibodies is related to the high maternal IgG level common in Africa.
本研究的目的是比较破伤风类毒素抗体（TTAB）和总IgG在非洲的胎盘转运情况，此前我们已证明在非洲麻疹抗体不存在从母亲向新生儿的传递。在法国巴黎有45对母婴，在中非加蓬的利伯维尔有134对母婴，在足月妊娠和正常分娩后对其进行了检测。巴黎TTAB和IgG的脐血/母血浓度比值均值分别为2.52和1.28，加蓬则分别为0.98和0.82。在利伯维尔的11对母婴中，母血和脐血中均未检测到TTAB，但在其他4名非洲新生儿（3%）中，母亲传递了低于破伤风保护水平的TTAB。其他数据（母亲IgG与相应TTAB浓度的脐血/母血比值呈负相关，以及在母亲IgG水平较低时TTAB的传递更好）表明，抗体主动胎盘转运的限制与非洲常见的高母亲IgG水平有关。
