Gendrel D, Richard-Lenoble D, Massamba M B, Picaud A, Moreno J L, Gendrel C, Baziomo J M, Francoual C, Blot P
Département de Pédiatrie, Höpital St. Vincent de Paul, Paris.
Arch Fr Pediatr. 1990 Dec;47(10):725-9.
Total IgG and tetanus antibodies were evaluated in 2 series of mother-child pairs: 50 in Paris and 134 in Africa. All pregnancies had been normal and birth weights greater than 3 kg. Cord blood mothers tetanus antibodies ratios were 1.5 in Paris and 0.98 in Libreville (p less than 0.01) respectively. Some African children were not protected, either due to the lack of response of their mothers to immunization (2.2%) or to an insufficient antibodies transplacental transport (2.9%), or to the lack of immunization of mothers (5.9%). On the contrary, all European children were protected, in spite of low maternal antibody levels. Likewise, in Paris cord blood IgG level was 12.24 g/l vs 9.42 in mothers (cord blood/mother ratio: 1.34) and in Africa 18.4 g/l in cord blood and 22.3 g/l in mothers (cord blood/mother ratio: 0.88; p less than 0.01). The correlations between maternal IgG levels and placental transfer rates indicate that the transplacental active transfer is limited by common high IgG levels in Africa, thus contributing to a decrease in protection of neonates, especially against tetanus in which humoral responses predominate.
在两组母婴对中评估了总IgG和破伤风抗体：巴黎有50对，非洲有134对。所有妊娠均正常，出生体重均超过3千克。巴黎脐带血中母亲破伤风抗体比率为1.5，利伯维尔为0.98（p<0.01）。一些非洲儿童未得到保护，原因要么是其母亲对免疫接种无反应（2.2%），要么是抗体经胎盘转运不足（2.9%），要么是母亲未进行免疫接种（5.9%）。相反，所有欧洲儿童都得到了保护，尽管母亲抗体水平较低。同样，在巴黎，脐带血IgG水平为12.24g/l，母亲为9.42g/l（脐带血/母亲比率：1.34），在非洲，脐带血为18.4g/l，母亲为22.3g/l（脐带血/母亲比率：0.88；p<0.01）。母亲IgG水平与胎盘转运率之间的相关性表明，在非洲，经胎盘的主动转运受到常见的高IgG水平限制，从而导致新生儿保护作用下降，尤其是在体液反应占主导的破伤风方面。
