Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, Lausanne, Switzerland.
Mucosal Immunol. 2013 Jan;6(1):83-92. doi: 10.1038/mi.2012.50. Epub 2012 Jul 18.
Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP in antiviral immunity is unknown. In this study we report a novel role for TSLP in promoting viral clearance and virus-specific CD8+ T-cell responses during influenza A infection. Comparing the immune responses of wild-type and TSLP receptor (TSLPR)-deficient mice, we show that TSLP was required for the expansion and activation of virus-specific effector CD8+ T cells in the lung, but not the lymph node. The mechanism involved TSLPR signaling on newly recruited CD11b+ inflammatory dendritic cells (DCs) that acted to enhance interleukin-15 production and expression of the costimulatory molecule CD70. Taken together, these data highlight the pleiotropic activities of TSLP and provide evidence for its beneficial role in antiviral immunity.
胸腺基质淋巴细胞生成素（TSLP）是一种黏膜组织相关细胞因子，在 Th2 型驱动的炎症性疾病的背景下得到了广泛研究。尽管 TSLP 在体外病毒感染时也会产生，但 TSLP 在抗病毒免疫中的作用尚不清楚。在这项研究中，我们报告了 TSLP 在促进甲型流感病毒清除和病毒特异性 CD8+T 细胞反应中的新作用。通过比较野生型和 TSLP 受体（TSLPR）缺陷型小鼠的免疫反应，我们发现 TSLP 是在肺部而不是淋巴结中扩增和激活病毒特异性效应 CD8+T 细胞所必需的。该机制涉及新募集的 CD11b+炎性树突状细胞（DC）上的 TSLPR 信号，其作用是增强白细胞介素-15 的产生和共刺激分子 CD70 的表达。总之，这些数据突出了 TSLP 的多效性活性，并为其在抗病毒免疫中的有益作用提供了证据。
