Laboratory of Molecular Immunology, Immunology Center, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, United States.
Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
Elife. 2021 Jan 13;10:e61912. doi: 10.7554/eLife.61912.
Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4 T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation. However, a direct role for TSLP in CD8 T-cell primary responses remains controversial and its role in memory CD8 T cell responses to secondary viral infection is unknown. Here, we investigate the role of TSLP in both primary and recall responses in mice using two different viral systems. Interestingly, TSLP limited the primary CD8 T-cell response to influenza but did not affect T cell function nor significantly alter the number of memory CD8 T cells generated after influenza infection. However, TSLP inhibited memory CD8 T-cell responses to secondary viral infection with influenza or acute systemic LCMV infection. These data reveal a previously unappreciated role for TSLP on recall CD8 T-cell responses in response to viral infection, findings with potential translational implications.
胸腺基质淋巴细胞生成素 (TSLP) 是一种细胞因子，可直接作用于 CD4 T 细胞和树突状细胞，促进哮喘、特应性皮炎和过敏炎症的发展。然而，TSLP 在 CD8 T 细胞初始反应中的直接作用仍存在争议，其在记忆性 CD8 T 细胞对二次病毒感染的反应中的作用尚不清楚。在这里，我们使用两种不同的病毒系统研究了 TSLP 在原发性和回忆性反应中的作用。有趣的是，TSLP 限制了流感病毒的原发性 CD8 T 细胞反应，但不影响 T 细胞功能，也不会显著改变流感感染后产生的记忆性 CD8 T 细胞数量。然而，TSLP 抑制了流感或急性系统性 LCMV 感染后的二次病毒感染的记忆性 CD8 T 细胞反应。这些数据揭示了 TSLP 在病毒感染后对回忆性 CD8 T 细胞反应的一个以前未被认识到的作用，这一发现具有潜在的转化意义。
