Steel M S, Naughton J M, Hopkins G W, Sinclair A J, O'Dea K
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Lipids. 1990 Nov;25(11):719-23. doi: 10.1007/BF02544040.
Male Sprague-Dawley rats were fed diets with 10%, 30%, or 50% of energy derived from fat for two weeks. The fats used were beef tallow, olive oil, peanut oil and butter. Aortic prostacyclin (PGI2) production, platelet aggregation and thromboxane A2 (TXA2) production and plasma and aortic phospholipid (PL) content were measured. Butter- and beef tallow-feeding reduced aortic PGI2 production and collagen-induced TXA2 production in a dose-dependent manner as the level of fat in the diet increased. Neither olive oil nor peanut oil had any effect on aortic PGI2 production or collagen-induced TXA2 production. Butter-feeding also resulted in a decrease in collagen-induced platelet aggregation; however, none of the other fats had any effect on collagen-induced platelet aggregation. The observed decreases in aortic PGI2 and collagen-induced TXA2 production were paralleled by similar decreases in aortic and plasma PL arachidonic acid content and an increase in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Only the most saturated fats, butter and beef tallow, had significant inhibitory effects on prostanoid production and platelet aggregation.
将雄性斯普拉格-道利大鼠分别喂食含10%、30%或50%能量来自脂肪的饲料，持续两周。所使用的脂肪为牛脂、橄榄油、花生油和黄油。测量主动脉前列环素（PGI2）生成量、血小板聚集情况、血栓素A2（TXA2）生成量以及血浆和主动脉磷脂（PL）含量。随着饮食中脂肪水平的升高，喂食黄油和牛脂会以剂量依赖的方式降低主动脉PGI2生成量以及胶原蛋白诱导的TXA2生成量。橄榄油和花生油对主动脉PGI2生成量或胶原蛋白诱导的TXA2生成量均无任何影响。喂食黄油还会导致胶原蛋白诱导的血小板聚集减少；然而，其他脂肪对胶原蛋白诱导的血小板聚集均无任何影响。观察到的主动脉PGI2和胶原蛋白诱导的TXA2生成量的减少与主动脉和血浆PL花生四烯酸含量的类似减少以及二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的增加同时出现。只有饱和度最高的脂肪，即黄油和牛脂，对前列腺素生成和血小板聚集有显著抑制作用。
