Howe Edmund
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Innov Clin Neurosci. 2012 May;9(5-6):47-51.
Patients with Alzheimer's disease may want to participate in research on Alzheimer's disease, but their participation involves exceptional considerations. Plans should be made for determining these patients' cognitive capacity on a regular basis; for example, throughout a study, cognitive capacity may decline, making it necessary for a patient's pre-designated surrogate decision maker to become more involved. Patients with Alzheimer's disease may also choose to designate someone other than their primary caregiver to be their surrogate decision maker. This article discusses these and other core ethical issues.
阿尔茨海默病患者可能希望参与阿尔茨海默病的研究，但他们的参与涉及特殊考量。应制定计划定期确定这些患者的认知能力；例如，在整个研究过程中，认知能力可能会下降，这就使得患者预先指定的替代决策者需要更多地参与进来。阿尔茨海默病患者也可能选择指定其主要照顾者以外的其他人作为其替代决策者。本文讨论了这些以及其他核心伦理问题。
