Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Bull Exp Biol Med. 2022 Jun;173(2):265-269. doi: 10.1007/s10517-022-05531-1. Epub 2022 Jun 23.
We studied structural rearrangement of the myometrium of C57BL/6 mice during the postpartum period under conditions of acute toxic hepatosis induced by CCl injection and its correction with immobilized hyaluronidase. In contrast to physiological pregnancy, involution of the myometrium in mice under conditions of acute toxic hepatosis were not completed by the 10th day of the postpartum period. When toxic hepatosis was corrected with immobilized hyaluronidase, the main mechanism of postpartum involution of the mouse myometrium was clasmacytosis, the process of postpartum involution was significantly accelerated, but not completed by the 10th day, probably due to reduced vascularization of the myometrium.
我们研究了在 CCl 注射引起的急性中毒性肝损伤条件下，C57BL/6 小鼠产后子宫结构重排及其固定化透明质酸酶的纠正作用。与生理妊娠相比，在急性中毒性肝损伤条件下，小鼠子宫的退化在产后第 10 天并未完成。当用固定化透明质酸酶纠正中毒性肝损伤时，小鼠产后子宫退化的主要机制是核碎裂，产后退化过程明显加快，但在第 10 天未完成，可能是由于子宫血管生成减少。
