Department of Internal Medicine, Kagoshima Kouseiren Hospital, 22-25 Tenpozan-cho, Kagoshima, 890-0061, Japan.
Diabetol Metab Syndr. 2012 Jul 18;4(1):34. doi: 10.1186/1758-5996-4-34.
Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis.
We enrolled 476 male subjects. Serum sd-LDL-C concentrations were determined using precipitation assays.
Subjects were divided into four groups based on triglyceride (TG) and LDL-C levels: A, TG < 150 mg/dl and LDL-C < 140 mg/dl; B, TG < 150 mg/dl and LDL-C ≥ 140 mg/dl; C, TG ≥ 150 mg/dl and LDL-C < 140 mg/dl; and D, TG ≥ 150 mg/dl and LDL-C ≥ 140 mg/dl. sd-LDL-C levels and the prevalence of fatty liver were significantly higher in groups B, C, and D than in group A. Subjects were also categorized into four groups based on serum sd-LDL-C levels; the prevalence of fatty liver significantly increased with increasing sd-LDL-C levels. Additionally, logistic regression analysis revealed an independent association between sd-LDL-C concentrations and fatty liver using such potential confounders as obesity and hyperglycemia as variables independent of elevated TG or LDL-C levels.
Fatty liver is a significant determinant of serum sd-LDL-C levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDL-C, resulting in increased sd-LDL-C levels.
本研究通过横断面分析探讨脂肪肝与小而密低密度脂蛋白胆固醇（sd-LDL-C）水平之间的潜在关联。
共纳入 476 名男性受试者。采用沉淀法测定血清 sd-LDL-C 浓度。
根据甘油三酯（TG）和 LDL-C 水平将受试者分为四组：A 组，TG<150mg/dl 且 LDL-C<140mg/dl；B 组，TG<150mg/dl 且 LDL-C≥140mg/dl；C 组，TG≥150mg/dl 且 LDL-C<140mg/dl；D 组，TG≥150mg/dl 且 LDL-C≥140mg/dl。与 A 组相比，B、C 和 D 组的 sd-LDL-C 水平和脂肪肝患病率显著更高。此外，根据血清 sd-LDL-C 水平将受试者分为四组，随着 sd-LDL-C 水平的升高，脂肪肝的患病率显著增加。另外，将肥胖和高血糖等潜在混杂因素作为独立于升高的 TG 或 LDL-C 水平的变量进行逻辑回归分析，结果显示 sd-LDL-C 浓度与脂肪肝之间存在独立关联。
脂肪肝是血清 sd-LDL-C 水平的重要决定因素，与肥胖或高血糖无关。脂肪肝可能改变肝脏对 TG 和 LDL-C 的代谢，导致 sd-LDL-C 水平升高。
