Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan.
Hepatol Res. 2008;38(11):1083-6. doi: 10.1111/j.1872-034X.2008.00383.x. Epub 2008 Jun 17.
Prevalence of fatty liver is increasing. In this study, to elucidate the factor that contributes most to recent increases in prevalence of fatty liver, we determined the independent predictors for the onset of fatty liver and compared these predictors between 2000 and 2005.
Japanese persons, aged 30-74 years, who participated in regular health checks at Kagoshima Kouseiren Medical Health Care Center (10 336 persons in 2000 and 11 011 persons in 2005) were enrolled in the study. Diagnosis of fatty liver was performed by ultrasonography. Body fat percentage (BFP) was determined using a bipedal bioimpedance instrument.
The prevalence of fatty liver has increased between 2000 and 2005 in men (33.3 vs 38.5% in 2000 vs 2005, respectively, P < 0.0001), but not in women (21.3 vs 21.0%, P = 0.8101). Logistic regression analysis revealed that both body mass index (BMI) and BFP are independent predictors of fatty liver in both men and women. BMI did not change in either men (23.4 +/- 2.9 vs 23.8 +/- 3.0 kg/m(2), P = 0.0528) or women (22.8 +/- 3.1 vs 22.8 +/- 3.3 kg/m(2), P = 0.9862) during the survey period. In contrast, BFP increased in men (20.6 +/- 4.7 vs 22.3 +/- 5.0 kg/m(2), P = 0.0003), but not in women (27.4 +/- 5.5 vs 28.4 +/- 5.9 kg/m(2), P = 0.3993). There was no significant change in triglycerides and glucose levels.
These results suggest that altered body composition, particularly increased BFP without an increase in BMI, has developed in men and is strongly associated with the increasing prevalence of fatty live amongst Japanese men.
脂肪肝的患病率正在上升。在这项研究中，为了阐明导致脂肪肝患病率最近上升的主要因素，我们确定了脂肪肝发病的独立预测因素，并比较了 2000 年和 2005 年的这些预测因素。
本研究纳入了在鹿儿岛 Kouseiren 医疗保健中心参加定期健康检查的年龄在 30-74 岁的日本人（2000 年 10336 人，2005 年 11011 人）。脂肪肝的诊断通过超声检查进行。体脂肪百分比（BFP）使用双足生物阻抗仪器测定。
2000 年至 2005 年间，男性脂肪肝的患病率有所上升（分别为 33.3%和 38.5%，P<0.0001），但女性无变化（分别为 21.3%和 21.0%，P=0.8101）。Logistic 回归分析显示，BMI 和 BFP 是男性和女性脂肪肝的独立预测因素。在整个研究期间，男性的 BMI 没有变化（分别为 23.4±2.9 和 23.8±3.0 kg/m²，P=0.0528），女性也没有变化（分别为 22.8±3.1 和 22.8±3.3 kg/m²，P=0.9862）。相比之下，男性的 BFP 增加（分别为 20.6±4.7 和 22.3±5.0 kg/m²，P=0.0003），而女性没有变化（分别为 27.4±5.5 和 28.4±5.9 kg/m²，P=0.3993）。甘油三酯和血糖水平没有显著变化。
这些结果表明，身体成分的改变，特别是 BMI 没有增加但 BFP 增加，在男性中已经出现，并且与日本男性中脂肪肝患病率的上升密切相关。
