Dewanjee M K, Rowland S M, Robinson R P, Dewanjee P K, Halgovich J L, Kapadvanjwala M, MacGregor D C, Serafini A N, Palatianos G M, Sfakianakis G N
University of Miami, School of Medicine, Department of Radiology, Florida 33101.
ASAIO Trans. 1989 Jul-Sep;35(3):365-8. doi: 10.1097/00002480-198907000-00062.
The dynamics of platelet deposition on control polyurethane catheters (CPC) and heparin-bonded polyurethane catheters (HBPC) were evaluated with In-111 labeled platelets (In-PLT) using a computerized gamma camera (CGC). Ten nonheparinized dogs (18-25 kg) had both femoral arteries catherized with 10 cm of CPC and HBPC (5 Fr.) 24 hr postinjection of 300-420 microcuries of In-PLT, and imaged for 3 hr with a gamma camera. Regional platelet deposition on three segments of catheters and the puncture site was determined. Catheters were harvested and radioactivity on the catheter segments (proximal: PROX, middle: MID, distal: DIST and puncture site: PS) of both was determined. From the platelet count in blood, and radioactivity in blood and segments of catheters, adjacent artery, and area of artery and catheter, the platelet-density [X10(3) (mean +/- S.D.)] on catheter and artery was calculated and tabulated. Proximal values were cath (CPC), 1289 +/- 1125; artery, 1355 +/- 587; cath (HBPC), 125 +/- 113; artery, 1149 +/- 1620. The middle values were cath (CPC), 1102 +/- 1109; artery, 1512 +/- 625; cath (HBPC), 132 +/- 108; artery, 1011 +/- 942. Distal values were cath (CPC), 780 +/- 584; artery, 132 +/- 108; cath (HBPC), 227 +/- 194; artery, 1457 +/- 1309. The puncture site values were cath (CPC), 106 +/- 382; artery, 1011 +/- 942; cath (HBPC), 164 +/- 135; artery, 1498 +/- 1240. The large standard deviation in retained platelets is due to embolization. The platelet-density and regional counts on catheter segments were lower with HBPC than CPC, as was the rate of platelet-deposition.(ABSTRACT TRUNCATED AT 250 WORDS)
使用计算机化γ相机（CGC），用铟 - 111标记的血小板（In - PLT）评估对照聚氨酯导管（CPC）和肝素结合聚氨酯导管（HBPC）上血小板沉积的动态情况。10只未使用肝素的犬（体重18 - 25千克），在注射300 - 420微居里In - PLT后24小时，将10厘米长的CPC和HBPC（5F）分别插入双侧股动脉，并用γ相机成像3小时。测定导管三段及穿刺部位的局部血小板沉积情况。收集导管并测定两者导管段（近端：PROX、中间：MID、远端：DIST和穿刺部位：PS）的放射性。根据血液中的血小板计数以及血液、导管段、相邻动脉、动脉和导管区域的放射性，计算并列出导管和动脉上的血小板密度[X10(3)（平均值±标准差）]。近端数值为：导管（CPC），1289±1125；动脉，1355±587；导管（HBPC），125±113；动脉，1149±1620。中间数值为：导管（CPC），1102±1109；动脉，1512±625；导管（HBPC），132±108；动脉，1011±942。远端数值为：导管（CPC），780±584；动脉，132±108；导管（HBPC），227±194；动脉，1457±1309。穿刺部位数值为：导管（CPC），106±382；动脉，1011±942；导管（HBPC），164±135；动脉，1498±1240。保留血小板的标准差较大是由于栓塞所致。HBPC导管段上的血小板密度和局部计数低于CPC，血小板沉积速率也是如此。（摘要截短于250字）
