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皮肤胶原性血管病:两名老年女性新发病例的描述及文献复习。

Cutaneous collagenous vasculopathy: description of two new cases in elderly women and review of the literature.

机构信息

Dermatology Service, Central University Hospital of Asturias, Oviedo, Spain.

出版信息

Dermatology. 2012;225(1):1-8. doi: 10.1159/000339770. Epub 2012 Jul 19.

Abstract

Cutaneous collagenous vasculopathy (CCV) is an idiopathic microangiopathy with characteristic histological findings. It was described in 2000, and 9 cases have since been described. Two women of 83 and 74 years consulted for long-standing telangiectasias. In case 1, they affected the limbs and trunk and in case 2 were located on the legs. Biopsies of these lesions showed dilated vascular structures whose walls were thickened due to deposition of eosinophilic hyaline material. The affected vessels were located in the superficial dermis in case 1, and in case 2 the reticular dermis was also affected. CCV is a microangiopathy of unknown etiology. Clinically it is indistinguishable from generalized essential telangiectasia and differs in its histology. CCV may be underdiagnosed, and some nonbiopsied cases of generalized essential telangiectasia may really be CCV. We contribute 2 new cases of this entity to help establish its clinical and epidemiological characteristics and make its etiology better known.

摘要

皮肤胶原性血管病(CCV)是一种特发性微血管病,具有特征性的组织学表现。它于 2000 年被描述,此后已经描述了 9 例。两名 83 岁和 74 岁的女性因长期出现毛细血管扩张就诊。在病例 1 中,病变累及四肢和躯干,而病例 2 则位于腿部。这些病变的活检显示扩张的血管结构,其壁因嗜酸性透明物质的沉积而增厚。在病例 1 中,受影响的血管位于真皮浅层,而在病例 2 中,网状真皮也受到影响。CCV 是一种病因不明的微血管瘤病。临床上与全身性特发性毛细血管扩张症无法区分,其组织学表现不同。CCV 可能被漏诊,一些未经活检的全身性特发性毛细血管扩张症病例可能实际上是 CCV。我们提供了该实体的 2 个新病例,以帮助确定其临床和流行病学特征,并更好地了解其病因。

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