St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
J Am Acad Dermatol. 2010 Nov;63(5):882-5. doi: 10.1016/j.jaad.2009.06.045. Epub 2010 May 6.
Cutaneous collagenous vasculopathy is characterized by generalized cutaneous telangiectasia and unique microscopic and ultrastructural vascular changes, consisting of marked collagen deposition within the vascular walls of the post-capillary venules in the superficial dermis. There are only 4 previous cases described in the medical literature, all in males, mostly middle-aged. We have recently seen two female patients with clinical and histopathologic features diagnostic of cutaneous collagenous vasculopathy, indicating that it is not restricted to males. As cutaneous collagenous vasculopathy can be clinically indistinguishable from generalized essential telangiectasia, and histopathologic studies are rarely performed for this condition, it is likely that cutaneous collagenous vasculopathy frequently passes unrecognized, but it may be more common than previously thought.
皮肤胶原性血管病的特征为全身性皮肤毛细血管扩张和独特的微观及超微结构血管变化，包括真皮浅层毛细血管后微静脉的血管壁内有明显的胶原沉积。在医学文献中仅有 4 例先前描述的病例，均为男性，大多数为中年。我们最近观察到两例女性患者，其临床表现和组织病理学特征诊断为皮肤胶原性血管病，表明其不限于男性。由于皮肤胶原性血管病在临床上可能与全身性特发性毛细血管扩张无法区分，并且很少对这种情况进行组织病理学研究，因此，皮肤胶原性血管病可能经常未被识别，但它可能比以前认为的更为常见。
