Hoeijmakers J H, Bootsma D
Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
Cancer Cells. 1990 Oct;2(10):311-20.
DNA repair plays a key role in the prevention of carcinogenesis and mutagenesis. Defective DNA repair has been implicated in various human hereditary disorders that predispose affected individuals to cancer. This article reviews our current understanding of one of major DNA repair systems--the nucleotide excision repair pathway--with special emphasis on the novel findings that have emerged from molecular genetic analysis of yeast and cultured mammalian cells.
DNA修复在预防癌变和诱变过程中起着关键作用。DNA修复缺陷与多种人类遗传性疾病有关，这些疾病使受影响个体易患癌症。本文综述了我们目前对主要DNA修复系统之一——核苷酸切除修复途径的理解，特别强调了从酵母和培养的哺乳动物细胞的分子遗传学分析中得出的新发现。
