Heckers S, Heinsen H, Heinsen Y, Beckmann H
Department of Psychiatry, University of Würzburg, FRG.
Biol Psychiatry. 1991 Mar 15;29(6):556-66. doi: 10.1016/0006-3223(91)90091-y.
Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes of cortex and white matter in schizophrenics. Striatal volume of schizophrenics was increased bilaterally reaching a significant level on the left side. Volumes of the globus pallidus were increased in both hemispheres reaching a significant level on the right side. After psychopathological differentiation, basal ganglia volume increase was also found in the subgroup of paranoid-hallucinatory schizophrenics.
对23例精神分裂症患者的大脑以及23例在性别、年龄和大脑半球方面严格匹配的对照者的大脑进行了皮质、白质和基底神经节的死后体积测定。将体视学方法应用于完整半球的连续冠状切片。我们发现精神分裂症患者的皮质和白质体积没有显著变化。精神分裂症患者双侧纹状体体积增加，左侧达到显著水平。两侧苍白球体积均增加，右侧达到显著水平。在进行精神病理学区分后，在偏执幻觉型精神分裂症亚组中也发现了基底神经节体积增加。
