Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, New York, USA.
PLoS One. 2012;7(7):e41373. doi: 10.1371/journal.pone.0041373. Epub 2012 Jul 19.
There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon, whereas T(H)1 and T(H)2 cells do not significantly vary by location. Transcriptional profiling analysis of paired pinch biopsies from different regions of the intestine identified significant differences in the metabolic state of the terminal ileum, cecum, and sigmoid colon. An increased proportion of T(H)17 cells was positively associated with expression of resistin (RETN) and negatively associated with expression of trefoil factor 1 (TFF1). These results suggest that CD4(+) T helper cells that are important in maintaining mucosal barrier function may be enriched in the cecum as a result of metabolic differences of the surrounding microenvironment.
越来越多的证据表明，CD4(+) T 细胞群的失调会导致肠道炎症，但在健康个体中，这些细胞群在整个肠道中的区域分布尚不清楚。在这里，我们表明 T(H)17、T(H)22 和 T(Reg)细胞在健康人的盲肠中比末端回肠和乙状结肠更为丰富，而 T(H)1 和 T(H)2 细胞在位置上没有显著差异。对来自肠道不同区域的配对活检进行的转录谱分析表明，末端回肠、盲肠和乙状结肠的代谢状态存在显著差异。T(H)17 细胞比例的增加与抵抗素 (RETN) 的表达呈正相关，与三叶因子 1 (TFF1) 的表达呈负相关。这些结果表明，在维持黏膜屏障功能方面很重要的 CD4(+)辅助性 T 细胞可能由于周围微环境的代谢差异而在盲肠中富集。
