Kawanishi M, Nakamoto A, Konemori G, Horiuchi I, Kajiyama G
Department of Biometrics, Hiroshima University, Japan.
Hiroshima J Med Sci. 1990 Sep;39(3):61-4.
In order to ascertain the most effective index for predicting coronary sclerosis, the concentration of lipids, lipoproteins, and apoproteins in serum were determined in 45 males aged over 44 with angiographically diagnosed effort angina and in 153 male controls aged over 44 without ischemic heart disease (IHD) on physical examination. The results of our study are summarized as follows. 1) Alcohol intake of 25 g/day or more and smoking of 20 cigarettes/day or more showed significant odds ratios of 0.47 and 2.33, respectively. 2) By decrease of 10 mg/dl in HDLC level or of 10 mg/dl in Apo-AI level, the possibility of coronary sclerosis increases twofold after adjusting the effects of confounders. 3) LDLC/HDLC and Apo-B/Apo-AI are effective indices for predicting coronary sclerosis and, in particular, the probability of coronary sclerosis increases 3.8 times by increase of 0.5 in Apo-B/Apo-AI.
为了确定预测冠状动脉硬化的最有效指标，我们对45名年龄在44岁以上、经血管造影诊断为劳力性心绞痛的男性以及153名年龄在44岁以上、体检无缺血性心脏病（IHD）的男性对照者测定了血清中的脂质、脂蛋白和载脂蛋白浓度。我们的研究结果总结如下：1）每日饮酒量25克及以上和每日吸烟20支及以上的优势比分别为0.47和2.33。2）高密度脂蛋白胆固醇（HDLC）水平每降低10毫克/分升或载脂蛋白A-I（Apo-AI）水平每降低10毫克/分升，在调整混杂因素的影响后，冠状动脉硬化的可能性增加两倍。3）低密度脂蛋白胆固醇/高密度脂蛋白胆固醇（LDLC/HDLC）和载脂蛋白B/载脂蛋白A-I（Apo-B/Apo-AI）是预测冠状动脉硬化的有效指标，特别是Apo-B/Apo-AI每增加0.5，冠状动脉硬化的概率增加3.8倍。
