祖细胞/干细胞移植修复心肌梗死：炒作还是希望？
Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope?
作者信息
Feng Yuliang, Wang Yuhua, Cao Nan, Yang Huangtian, Wang Yigang
机构信息
Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA.
出版信息
Ann Palliat Med. 2012;1(1):65-77. doi: 10.3978/j.issn.2224-5820.2012.04.01.
Abstract
Despite significant therapeutic advances, heart failure remains the predominant cause of mortality worldwide. Currently, progenitor/stem cell biology holds great promise for a new era of cell-based therapy for salvaging the failing heart. However, the translational arm of progenitor/stem cell science is in a relatively primitive state. For the time being, the clinical trials have been both encouraging and disappointing. How to improve the engraftment, long-term survival and appropriate differentiation of transplanted progenitor/stem cell within the cardiovascular tissues may be the key issues to facilitate the transition of cardiogenic stem cell research from bench to bedside. In this review article we discuss the state-of-the-art in adult stem cell therapies for cardiovascular diseases and approaches to release cardiac regeneration potentials of progenitor/stem cells.
摘要
尽管在治疗方面取得了重大进展，但心力衰竭仍是全球主要的死亡原因。目前，祖细胞/干细胞生物学为基于细胞的治疗挽救衰竭心脏的新时代带来了巨大希望。然而，祖细胞/干细胞科学的转化领域仍处于相对原始的状态。目前，临床试验既有令人鼓舞的一面，也有令人失望的一面。如何提高移植的祖细胞/干细胞在心血管组织内的植入、长期存活和适当分化，可能是促进心脏干细胞研究从实验室走向临床的关键问题。在这篇综述文章中，我们讨论了成体干细胞治疗心血管疾病的最新进展以及释放祖细胞/干细胞心脏再生潜能的方法。
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