Williams Gareth R, Chatterton Nicholas P, Nazir Tahir, Yu Deng-Guang, Zhu Li-Min, Branford-White Christopher J
School of Human Sciences, Faculty of Life Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.
Ther Deliv. 2012 Apr;3(4):515-33. doi: 10.4155/tde.12.17.
In this review article, some key challenges in drug delivery are first introduced and methods that have been applied in attempts to solve them enumerated. Particularly intractable problems are highlighted: these include issues of solubility, targeting and drug degradation. The technique of electrospinning is subsequently introduced, and the influence of processing parameters on the fibers produced discussed. The potential of electrospun nanofibers in drug delivery is then explored, with examples given from the recent literature to illustrate how fibers can be used to overcome hurdles in drug solubility, degradation and targeting. Future perspectives and challenges are also considered.
在这篇综述文章中，首先介绍了药物递送中的一些关键挑战，并列举了为解决这些挑战而采用的方法。特别强调了一些棘手的问题：包括溶解度、靶向性和药物降解等问题。随后介绍了静电纺丝技术，并讨论了加工参数对所生产纤维的影响。接着探讨了静电纺丝纳米纤维在药物递送中的潜力，并引用近期文献中的实例来说明纤维如何用于克服药物溶解度、降解和靶向性方面的障碍。还考虑了未来的前景和挑战。
