Delehanty James B, Boeneman Kelly, Bradburne Christopher E, Robertson Kelly, Bongard Jason E, Medintz Igor L
Center for Bio/Molecular Science & Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA.
Ther Deliv. 2010 Sep;1(3):411-33. doi: 10.4155/tde.10.27.
The use of peptides to mediate the delivery and uptake of nanoparticle (NP) materials by mammalian cells has grown significantly over the past 10 years. This area of research has important implications for the development of new therapeutic materials and for the emerging field of NP-mediated drug delivery. In this review, we highlight recent advances in the delivery of various NPs by some of the more commonly employed cellular delivery peptides and discuss important related factors such as NP-peptide bioconjugation, uptake efficiency, intracellular fate and toxicity. We also highlight various demonstrations of therapeutic applications of NP-peptide conjugates where appropriate. The paper concludes with a brief forward-looking perspective discussing what can be expected as this field develops in the coming years.
在过去十年中，利用肽介导哺乳动物细胞对纳米颗粒（NP）材料的递送和摄取的研究显著增加。这一研究领域对于新型治疗材料的开发以及NP介导的药物递送这一新兴领域具有重要意义。在本综述中，我们重点介绍了一些较为常用的细胞递送肽在递送各种NP方面的最新进展，并讨论了诸如NP-肽生物缀合、摄取效率、细胞内命运和毒性等重要相关因素。在适当的情况下，我们还重点介绍了NP-肽缀合物治疗应用的各种实例。本文最后以简要的前瞻性视角讨论了随着该领域在未来几年的发展可以预期的情况。
