Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Int J Gynaecol Obstet. 2012 Oct;119(1):26-9. doi: 10.1016/j.ijgo.2012.05.029. Epub 2012 Jul 24.
To evaluate the effectiveness of autologous platelet-rich plasma (PRP) applications in the treatment of benign cervical ectopy.
Symptomatic women with benign cervical ectopy (n=120) were randomized to a PRP or a laser group. In the PRP group, PRP was applied twice on the cervical erosion with a 1-week interval. In the laser group, an Nd-YAG laser was used once for tissue vaporization.
The complete cure rates were 93.7% for the PRP and 92.4% for the laser group (P>0.05). The mean time to re-epithelialization was significantly shorter in the PRP (6.41 ± 2.05 weeks) than in the laser group (8.28 ± 1.72 weeks) (P<0.01). The rate of adverse treatment effects (i.e. vaginal discharge or vaginal bleeding) was much lower in the PRP than that in the laser group (P<0.01) and the effects were milder. Eleven patients in the PRP group had mild or moderate vaginal bleeding after treatment but none had heavy bleeding. Of 25 patients with vaginal bleeding in the laser group, 2 had heavy bleeding necessitating tamponade.
Autologous PRP applications appear promising for the treatment of cervical ectopy in symptomatic women, as they generate a shorter tissue healing time and milder adverse effects than laser treatment.
评估自体富血小板血浆（PRP）在治疗良性宫颈柱状上皮异位中的有效性。
将 120 例有症状的良性宫颈柱状上皮异位患者随机分为 PRP 组和激光组。PRP 组在宫颈糜烂处应用 PRP 两次，间隔 1 周。激光组采用 Nd-YAG 激光一次性进行组织汽化。
PRP 组完全治愈率为 93.7%，激光组为 92.4%（P>0.05）。PRP 组的上皮再上皮化时间明显短于激光组（6.41±2.05 周 vs 8.28±1.72 周）（P<0.01）。PRP 组不良反应（即阴道分泌物或阴道出血）发生率明显低于激光组（P<0.01），且程度较轻。PRP 组 11 例患者治疗后出现轻度或中度阴道出血，但无 1 例发生大出血。激光组 25 例阴道出血患者中，2 例发生大出血，需行填塞。
自体 PRP 应用似乎是治疗有症状的女性宫颈柱状上皮异位的一种有前途的方法，因为它比激光治疗产生更短的组织愈合时间和更轻微的不良反应。
