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随机对照试验中接受运动干预的乳腺癌辅助治疗幸存者的 5 年随访结果:是否存在持久效应?

Five-year follow-up of participants in a randomised controlled trial showing benefits from exercise for breast cancer survivors during adjuvant treatment. Are there lasting effects?

机构信息

School of Psychological Sciences and Health, University of Strathclyde, 76 Southbrae Drive, Glasgow G13 1PP, UK.

出版信息

J Cancer Surviv. 2012 Dec;6(4):420-30. doi: 10.1007/s11764-012-0233-y. Epub 2012 Jul 27.

DOI:10.1007/s11764-012-0233-y
PMID:22836201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3505536/
Abstract

PURPOSE

In an earlier randomised controlled trial, we showed that early stage breast cancer patients who received a supervised exercise programme, with discussion of behaviour change techniques, had psychological and functional benefits 6 months after the intervention. The purpose of this study was to determine if benefits observed at 6 months persisted 18 and 60 months later.

METHODS

Women who were in the original trial were contacted at 18 and 60 months after intervention. Original measures were repeated.

RESULTS

Of the 148 women from the original study who agreed to be contacted again, 114 attended for follow-up at 18 months and 87 at 60 months. Women in the original intervention group reported more leisure time physical activity and more positive moods at 60 months than women in the original control group. Irrespective of original group allocation, women who were more active consistently reported lower levels of depression and increased quality of life compared to those who were less active.

CONCLUSIONS

We have shown that there are lasting benefits to an exercise intervention delivered during treatment to breast cancer survivors. Regular activity should be encouraged for women with early stage breast cancer as this can have lasting implications for physical and psychological functioning.

摘要

目的

在之前的一项随机对照试验中,我们发现接受监督下的运动方案(同时讨论行为改变技术)的早期乳腺癌患者,在干预后 6 个月时具有心理和功能获益。本研究旨在确定在 6 个月时观察到的益处是否能持续到 18 个月和 60 个月后。

方法

在干预后 18 个月和 60 个月时联系最初试验中的女性。重复原始测量。

结果

在同意再次联系的 148 名原始研究女性中,114 名在 18 个月时进行了随访,87 名在 60 个月时进行了随访。与原始对照组相比,原始干预组的女性在 60 个月时报告了更多的闲暇时间体育活动和更积极的情绪。无论原始组分配如何,与不活跃的女性相比,持续更活跃的女性报告抑郁程度更低,生活质量更高。

结论

我们已经表明,在乳腺癌幸存者治疗期间进行的运动干预有持久的益处。应鼓励早期乳腺癌女性进行定期活动,因为这对身体和心理功能有持久的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/ca3cdcd95254/11764_2012_233_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/5c1570e63cd4/11764_2012_233_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/93c6a8a75bb3/11764_2012_233_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/95dbe329147f/11764_2012_233_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/904eb06a1719/11764_2012_233_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/ca3cdcd95254/11764_2012_233_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/5c1570e63cd4/11764_2012_233_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/93c6a8a75bb3/11764_2012_233_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/95dbe329147f/11764_2012_233_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/904eb06a1719/11764_2012_233_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b87/3505536/ca3cdcd95254/11764_2012_233_Fig5_HTML.jpg

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