Stuart Jeffrey A, Liang Ping, Luo Xuemei, Page Melissa M, Gallagher Emily J, Christoff Casey A, Robb Ellen L
Department of Biological Sciences, Brock University, St. Catharines, ON, Canada, L2S 3A1,
Age (Dordr). 2013 Oct;35(5):1937-47. doi: 10.1007/s11357-012-9458-y. Epub 2012 Jul 27.
Discovering key cellular and molecular traits that promote longevity is a major goal of aging and longevity research. One experimental strategy is to determine which traits have been selected during the evolution of longevity in naturally long-lived animal species. This comparative approach has been applied to lifespan research for nearly four decades, yielding hundreds of datasets describing aspects of cell and molecular biology hypothesized to relate to animal longevity. Here, we introduce a Comparative Cellular and Molecular Biology of Longevity Database, available at ( http://genomics.brocku.ca/ccmbl/ ), as a compendium of comparative cell and molecular data presented in the context of longevity. This open access database will facilitate the meta-analysis of amalgamated datasets using standardized maximum lifespan (MLSP) data (from AnAge). The first edition contains over 800 data records describing experimental measurements of cellular stress resistance, reactive oxygen species metabolism, membrane composition, protein homeostasis, and genome homeostasis as they relate to vertebrate species MLSP. The purpose of this review is to introduce the database and briefly demonstrate its use in the meta-analysis of combined datasets.
发现促进长寿的关键细胞和分子特征是衰老与长寿研究的一个主要目标。一种实验策略是确定在自然长寿动物物种的长寿进化过程中哪些特征被选择了。这种比较方法已应用于寿命研究近四十年，产生了数百个数据集，描述了假设与动物长寿相关的细胞和分子生物学方面。在此，我们引入一个长寿比较细胞与分子生物学数据库（网址：http://genomics.brocku.ca/ccmbl/ ），作为在长寿背景下呈现的比较细胞和分子数据的汇编。这个开放获取数据库将有助于使用标准化的最大寿命（MLSP）数据（来自AnAge）对合并数据集进行元分析。第一版包含800多条数据记录，描述了与脊椎动物物种MLSP相关的细胞抗应激性、活性氧代谢、膜组成、蛋白质稳态和基因组稳态的实验测量结果。本综述的目的是介绍该数据库，并简要展示其在合并数据集元分析中的应用。
