Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Nucleic Acids Res. 2013 Jan;41(Database issue):D1027-33. doi: 10.1093/nar/gks1155. Epub 2012 Nov 27.
The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms; (ii) AnAge, an extensive collection of longevity records and complementary traits for >4000 vertebrate species; and (iii) GenDR, a newly incorporated database, containing both gene mutations that interfere with dietary restriction-mediated lifespan extension and consistent gene expression changes induced by dietary restriction. Since its creation about 10 years ago, major efforts have been undertaken to maintain the quality of data in HAGR, while further continuing to develop, improve and extend it. This article briefly describes the content of HAGR and details the major updates since its previous publications, in terms of both structure and content. The completely redesigned interface, more intuitive and more integrative of HAGR resources, is also presented. Altogether, we hope that through its improvements, the current version of HAGR will continue to provide users with the most comprehensive and accessible resources available today in the field of biogerontology.
人类衰老基因组资源（HAGR，http://genomics.senescence.info）是一个免费的在线研究数据库和工具集合，用于研究衰老的生物学和遗传学。HAGR 现在拥有几个具有高质量人工整理数据的数据库：（i）GenAge，一个与人类和模式生物衰老相关的基因数据库；（ii）AnAge，一个包含超过 4000 种脊椎动物物种的长寿记录和补充特征的广泛收集；（iii）GenDR，一个新纳入的数据库，包含干扰饮食限制介导的寿命延长的基因突变和饮食限制诱导的一致基因表达变化。自大约 10 年前创建以来，已经做出了重大努力来维护 HAGR 中数据的质量，同时继续开发、改进和扩展它。本文简要描述了 HAGR 的内容，并详细介绍了自上次出版物以来在结构和内容方面的主要更新。还介绍了完全重新设计的界面，它更直观，更集成了 HAGR 资源。总的来说，我们希望通过改进，当前版本的 HAGR 将继续为用户提供在生物老年学领域今天可用的最全面和最容易访问的资源。
