编码小t抗原的BK病毒DNA片段的核苷酸序列。
Nucleotide sequence of the BK virus DNA segment encoding small t antigen.
作者信息
Dhar R, Seif I, Khoury G
出版信息
Proc Natl Acad Sci U S A. 1979 Feb;76(2):565-9. doi: 10.1073/pnas.76.2.565.
Abstract
The nucleotide sequence from 0.64 to 0.53 map units in the BK virus genome coding for the small t protein has been determined. There is only one open reading frame that can code for a polypeptide of 172 amino acids, the putative small t protein. Beyond this segment, multiple termination codons are present in all three reading frames. There is considerable nucleotide and amino acid sequence homology between this region of BK virus and the analogous region of simian virus 40, especially in the proximal portion from 0.64 to 0.60 map units which is most likely common to the small t and large T BK virus proteins. A comparison of the conserved sequences within the early papovavirus genes both confirms the evolutionary relationship between these viruses and suggests the amino acid composition of the regions required for T antigen functions.
摘要
已确定BK病毒基因组中编码小t蛋白的0.64至0.53个图距单位的核苷酸序列。只有一个开放阅读框能够编码一个由172个氨基酸组成的多肽，即推定的小t蛋白。在该片段之外，所有三个阅读框中均存在多个终止密码子。BK病毒的这一区域与猴病毒40的类似区域之间存在相当程度的核苷酸和氨基酸序列同源性，尤其是在0.64至0.60个图距单位的近端部分，这很可能是BK病毒小t蛋白和大T蛋白共有的。对早期乳头瘤多瘤空泡病毒基因内保守序列的比较既证实了这些病毒之间的进化关系，也提示了T抗原功能所需区域的氨基酸组成。
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