马来西亚药用植物内生真菌抗菌和抗肿瘤活性的初步筛选
Preliminary screening of endophytic fungi from medicinal plants in malaysia for antimicrobial and antitumor activity.
作者信息
Radu Son, Kqueen Cheah Yoke
机构信息
Department of Biotechnology, Faculty of Food Science and Biotechnology, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
出版信息
Malays J Med Sci. 2002 Jul;9(2):23-33.
Abstract
The screening of antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, yeast and fungi was carried out on isopropanol extracts prepared from 121 isolates of endophytic fungi isolated from medicinal plants in Malaysia. Sensitivity was found to vary among the microorganisms. Bacillus subtilis, Saccharomyces cerevisiae and Alternaria sp. were susceptible to extracts from three, two and two isolates of endophytic fungi, respectively. None were found effective against Salmonella typhimurium. Sixteen endophytic fungal isolates tested were also found to exhibit antitumor activity in the yeast cell-based assay.
摘要
对从马来西亚药用植物中分离出的121株内生真菌制备的异丙醇提取物进行了抗革兰氏阳性菌、革兰氏阴性菌、酵母和真菌的抗菌活性筛选。发现不同微生物之间的敏感性存在差异。枯草芽孢杆菌、酿酒酵母和链格孢分别对三株、两株和两株内生真菌的提取物敏感。未发现对鼠伤寒沙门氏菌有效的提取物。在基于酵母细胞的试验中，还发现16株受试内生真菌具有抗肿瘤活性。
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