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[睡眠障碍对神经内分泌和自主神经功能的影响]

[The impact of sleep disturbances on neuroendocrine and autonomic functions].

作者信息

Suzuki Keisuke, Miyamoto Masayuki, Miyamoto Tomoyuki, Sakuta Hideki, Hirata Koichi

机构信息

Department of Neurology, Dokkyo Medical University.

出版信息

Nihon Rinsho. 2012 Jul;70(7):1169-76.

Abstract

Sleep plays a pivotal role in the regulation of autonomic functions such as heart rate, body temperature and blood pressure. It also influences endocrine functions, including the secretion of pituitary hormones, leptin and ghrelin, as well as energy homeostasis. In non-rapid eye movement (NREM) sleep, autonomic functioning is relatively stable with a parasympathetic dominance, whereas autonomic activity is considerably variable in REM sleep. Here, we review the regulatory role of sleep on autonomic functioning in REM and NREM sleep. We also review the role of endocrine hormones, i.e., the secretion patterns of hormones that are influenced by sleep-wake homeostasis and circadian rhythm variably. Additionally, we discuss the effect of sleep curtailment on the risk of developing metabolic diseases such as diabetes and obesity.

摘要

睡眠在调节诸如心率、体温和血压等自主功能方面起着关键作用。它还会影响内分泌功能,包括垂体激素、瘦素和胃饥饿素的分泌,以及能量平衡。在非快速眼动(NREM)睡眠中,自主功能相对稳定,以副交感神经占主导,而在快速眼动睡眠中自主活动则变化很大。在此,我们综述睡眠对快速眼动和非快速眼动睡眠中自主功能的调节作用。我们还综述内分泌激素的作用,即受睡眠-觉醒平衡和昼夜节律变化影响的激素分泌模式。此外,我们讨论了睡眠不足对患糖尿病和肥胖症等代谢性疾病风险的影响。

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