Laboratory of Engineering and Chemistry of Products, School of Chemical Engineering, University of Campinas, UNICAMP, Campinas, Brazil.
Macromol Biosci. 2012 Sep;12(9):1253-64. doi: 10.1002/mabi.201200060. Epub 2012 Jul 30.
A microstructured composite material made of collagen hydrogel (matrix) and silk fibroin microfibers (randomly oriented reinforcing fibers) is investigated in order to conjugate the mechanical resistance of fibroin with the suitable biological performance of collagen to design new scaffolds for vascular tissue engineering. Results show that fibroin microfibers and collagen fibrils have suitable interfacial adhesion, and the scaffold exhibits improved mechanical properties if compared with a pure collagen hydrogel. Furthermore, the overall biological performance is improved.
研究了一种由胶原水凝胶（基质）和丝素微纤维（随机取向的增强纤维）组成的微结构复合材料，旨在将丝素的机械强度与胶原的合适生物学性能相结合，设计用于血管组织工程的新型支架。结果表明，丝素微纤维和胶原原纤维具有合适的界面附着力，如果与纯胶原水凝胶相比，支架的机械性能得到了改善。此外，整体生物性能也得到了提高。
