Thomas Jyothi, Jacob George P, Abraham Lekha, Noushad Babu
Manipal College of Allied Health Sciences, Manipal University, Manipal, India.
Australas Med J. 2012;5(4):221-6. doi: 10.4066/AMJ.2012.1035. Epub 2012 Apr 30.
Smoking, both active and passive, creates a plethora of health-related problems, which primarily affect the cardiovascular and respiratory systems. There is very little evidence on the effects of tobacco smoke on the eye, especially regarding anterior ocular surface related pathology. This study was undertaken to determine the effects of smoking on the ocular surface and the tear film in smokers.
A total of 51 (102 eyes) smokers and 50 (100 eyes) age-and gender-matched healthy non-smokers were included in this study. The ocular surface was evaluated by measuring tear film break-up time, surface staining with fluorescein, and corneal and conjunctival sensitivities, and by completing the Schirmer's II test. Data was analysed using Statistical Package for Social Sciences (SPSS) version 11.5. A p value less than 0.05 was considered statistically significant.
The smoker group had significantly lower tear film break-up time, and corneal and conjunctival sensitivity than the nonsmoker group. Punctate staining was significantly higher in the smoker group than the non-smoker group. There was no statistically significant difference in Schirmer's II test results between the smoker and non-smoker group.
Smoking caused adverse effects on the precorneal tear film and there was strong association between smoking and tear film instability. Although a causative relationship could not be determined, there is a need for further longitudinal studies.
主动吸烟和被动吸烟都会引发大量与健康相关的问题，主要影响心血管和呼吸系统。关于烟草烟雾对眼睛的影响，尤其是与眼前段眼表相关病理的证据非常少。本研究旨在确定吸烟对吸烟者眼表和泪膜的影响。
本研究共纳入51名（102只眼）吸烟者和50名（100只眼）年龄及性别匹配的健康非吸烟者。通过测量泪膜破裂时间、荧光素表面染色、角膜和结膜敏感度以及完成SchirmerⅡ试验来评估眼表。使用社会科学统计软件包（SPSS）11.5版进行数据分析。p值小于0.05被认为具有统计学意义。
吸烟者组的泪膜破裂时间、角膜和结膜敏感度显著低于非吸烟者组。吸烟者组的点状染色显著高于非吸烟者组。吸烟者组和非吸烟者组之间SchirmerⅡ试验结果无统计学显著差异。
吸烟对角膜前泪膜产生不良影响，吸烟与泪膜不稳定之间存在密切关联。尽管无法确定因果关系，但仍需要进一步的纵向研究。
