Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Diagn Pathol. 2012 Jul 31;7:89. doi: 10.1186/1746-1596-7-89.
Squamous metaplasia presenting in noninvasive mucinous cystic neoplasm (MCN) of the pancreas is extremely rare. We described a case of 39-year-old Chinese female with a 5-year history of a slow growing mass in the left upper abdomen and an 18-month history of surgical incision exudation. The patient underwent cystojejunostomy, laparotomy and distal pancreatectomy consecutively because of the initial diagnosis of "pancreatic cyst". The histological section showed columnar mucin-producing epithelium formed small papillary projections and extensively visible squamous metaplasia. Therefore the diagnosis of "noninvasive MCN with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia" was made finally. The squamous component of the pancreas may be derived from pluripotent stem cells, and may be in association with cystojejunostomy. Virtual slides: The virtual slide(s) for this article can be found here http://www.diagnosticpathology.diagnomx.eu/vs/1322364365718540.
胰腺的非浸润性黏液性囊性肿瘤（MCN）中出现鳞状上皮化生极为罕见。我们描述了 1 例 39 岁中国女性患者，其病史为 5 年左上腹缓慢生长肿块和 18 个月手术切口渗出。由于最初诊断为“胰腺囊肿”，患者先后接受了囊空肠吻合术、剖腹术和胰体尾切除术。组织学切片显示柱状黏液产生上皮形成小乳头状突起，并广泛可见鳞状上皮化生。因此最终诊断为“胰腺非浸润性 MCN 伴中等级别异型增生和广泛鳞状上皮化生”。胰腺的鳞状成分可能来自多能干细胞，并可能与囊空肠吻合术有关。虚拟切片：本文的虚拟切片可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/1322364365718540。
