两种新型喹诺酮类药物依诺沙星和E-3846的体外活性
In vitro activities of irloxacin and E-3846, two new quinolones.
作者信息
García-Rodríguez J A, García Sánchez J E, Muñoz Bellido J L, Trujillano I
机构信息
Departamento de Microbiología, Hospital Clínico Universitario, Salamanca, Spain.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1262-7. doi: 10.1128/AAC.34.6.1262.
Irloxacin and E-3846 are two new fluorinated quinolones. We evaluated the activities of these antimicrobial agents, ciprofloxacin, ofloxacin, enoxacin, pefloxacin, norfloxacin, and nalidixic acid against 1,161 bacterial strains. Ciprofloxacin was the most active quinolone. Irloxacin did not show great activity. The activity of E-3846 against gram-negative bacteria was similar to those of ofloxacin and pefloxacin, and E-3846 was the most active quinolone against gram-positive bacteria and anaerobes.
伊洛沙星和E-3846是两种新型氟喹诺酮类药物。我们评估了这些抗菌药物、环丙沙星、氧氟沙星、依诺沙星、培氟沙星、诺氟沙星和萘啶酸对1161株细菌的活性。环丙沙星是活性最强的喹诺酮类药物。伊洛沙星未表现出很强的活性。E-3846对革兰氏阴性菌的活性与氧氟沙星和培氟沙星相似，且E-3846是对革兰氏阳性菌和厌氧菌活性最强的喹诺酮类药物。
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