Khardori N, Shawar R, Gupta R, Rosenbaum B, Rolston K
Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield 62794-9230.
Antimicrob Agents Chemother. 1993 Apr;37(4):882-4. doi: 10.1128/AAC.37.4.882.
The in vitro activities of various quinolones, two new aminoglycosides, a new cephamycin analog (cefmetazole) and a new spectinomycin analog (trospectomycin), imipenem, and trimethoprim-sulfamethoxazole against 26 isolates of Nocardia asteroides, 7 isolates of N. brasiliensis, and 6 isolates of N. caviae were determined by a broth microdilution method. The three new quinolones, PD 117558, PD 117596 and PD 112739, inhibited 90% of N. asteroides at 1 to 2 micrograms/ml, and two new aminoglycosides, SCH 21420 and SCH 22591, inhibited 90% of N. asteroides at 2 to 4 micrograms/ml. Among the beta-lactams, cefmetazole was more active than imipenem. N. brasiliensis and N. caviae isolates were also very susceptible to the three quinolones (MICs for 50% of the isolates, 0.25 to 1 microgram/ml) and the two aminoglycosides (MICs for 50% of the isolates, 1 to 2 micrograms/ml). Cefmetazole was moderately active against N. brasiliensis, whereas imipenem showed poor activity against both of these species.
采用肉汤微量稀释法测定了多种喹诺酮类药物、两种新型氨基糖苷类药物、一种新型头孢霉素类似物（头孢美唑）、一种新型大观霉素类似物（曲砜霉素）、亚胺培南以及甲氧苄啶-磺胺甲恶唑对26株星形诺卡菌、7株巴西诺卡菌和6株豚鼠诺卡菌的体外活性。三种新型喹诺酮类药物PD 117558、PD 117596和PD 112739在1至2微克/毫升时可抑制90%的星形诺卡菌，两种新型氨基糖苷类药物SCH 21420和SCH 22591在2至4微克/毫升时可抑制90%的星形诺卡菌。在β-内酰胺类药物中，头孢美唑比亚胺培南活性更强。巴西诺卡菌和豚鼠诺卡菌分离株对这三种喹诺酮类药物（50%分离株的MIC为0.25至1微克/毫升）和两种氨基糖苷类药物（50%分离株的MIC为1至2微克/毫升）也非常敏感。头孢美唑对巴西诺卡菌有中度活性，而亚胺培南对这两种菌的活性均较差。
