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一家急症护理医院中对氨苄西林耐药的肠球菌属菌种

Ampicillin-resistant enterococcal species in an acute-care hospital.

作者信息

Oster S E, Chirurgi V A, Goldberg A A, Aiken S, McCabe R E

机构信息

Medical Service, Veterans Administration Medical Center, Martinez, California 94553.

出版信息

Antimicrob Agents Chemother. 1990 Sep;34(9):1821-3. doi: 10.1128/AAC.34.9.1821.

DOI:10.1128/AAC.34.9.1821
PMID:2285299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171938/
Abstract

A prospective review of all enterococcal isolates for 13 months showed that 9.0% were resistant to ampicillin (MIC, greater than or equal to 16 micrograms/ml; zone diameter, less than 15 mm), as determined by the Vitek system, disk diffusion, microdilution MIC testing, and macrodilution MIC testing. All were beta-lactamase negative. A total of 19 and 3 resistant isolates were from urine and intravascular sites, respectively. Ampicillin-resistant enterococci appear to be a growing clinical problem.

摘要

对所有肠球菌分离株进行的为期13个月的前瞻性评估表明，根据Vitek系统、纸片扩散法、微量稀释法MIC检测和常量稀释法MIC检测，9.0%的分离株对氨苄西林耐药（MIC大于或等于16微克/毫升；抑菌圈直径小于15毫米）。所有分离株均为β-内酰胺酶阴性。分别有19株和3株耐药分离株来自尿液和血管内部位。耐氨苄西林肠球菌似乎是一个日益严重的临床问题。

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本文引用的文献

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Enterococci. Biologic and epidemiologic characteristics and in vitro susceptibility.肠球菌。生物学和流行病学特征以及体外药敏性。
Arch Intern Med. 1982 Oct 25;142(11):2006-9. doi: 10.1001/archinte.142.11.2006.
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Susceptibilities of enterococci to twelve antibiotics.肠球菌对十二种抗生素的敏感性。
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Enterococcal infections in patients treated with moxalactam.接受羟羧氧酰胺菌素治疗患者的肠球菌感染
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Transition from resistance to hypersusceptibility to beta-lactam antibiotics associated with loss of a low-affinity penicillin-binding protein in a Streptococcus faecium mutant highly resistant to penicillin.在一株对青霉素高度耐药的粪肠球菌突变体中，从对β-内酰胺类抗生素耐药转变为超敏，这与一种低亲和力青霉素结合蛋白的缺失有关。
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One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin.一两种低亲和力青霉素结合蛋白可能是屎肠球菌对苄青霉素敏感性差异的原因。
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Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis.两种产青霉素酶粪肠球菌（肠球菌）菌株的特性鉴定与比较。
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Single-concentration broth microdilution test for detection of high-level aminoglycoside resistance in enterococci.用于检测肠球菌中高水平氨基糖苷类耐药性的单浓度肉汤微量稀释试验。
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Susceptibility of enterococci. I. Inhibitory and bactericidal activity of several chemoantibiotics against Streptococcus faecalis and Streptococcus faecium.肠球菌的敏感性。一、几种化学抗生素对粪链球菌和屎肠球菌的抑制及杀菌活性。
Chemioterapia. 1986 Oct;5(5):302-8.
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