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1
Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis.两种产青霉素酶粪肠球菌（肠球菌）菌株的特性鉴定与比较。
Antimicrob Agents Chemother. 1988 Jan;32(1):122-4. doi: 10.1128/AAC.32.1.122.
2
Comparison of ampicillin-sulbactam with vancomycin for treatment of experimental endocarditis due to a beta-lactamase-producing, highly gentamicin-resistant isolate of Enterococcus faecalis.氨苄西林-舒巴坦与万古霉素治疗由产β-内酰胺酶、对庆大霉素高度耐药的粪肠球菌分离株引起的实验性心内膜炎的比较。
Antimicrob Agents Chemother. 1993 Jul;37(7):1447-51. doi: 10.1128/AAC.37.7.1447.
3
[Bactericidal activity of combinations of ticarcillin-clavulanic acid or other beta-lactams (amoxicillin, piperacillin-tazobactam, ticarcillin) with gentamicin against Enterococcus faecalis and E. faecium].替卡西林-克拉维酸或其他β-内酰胺类抗生素（阿莫西林、哌拉西林-他唑巴坦、替卡西林）与庆大霉素联合使用对粪肠球菌和屎肠球菌的杀菌活性
Pathol Biol (Paris). 1995 Apr;43(4):245-52.
4
In vitro studies of plasmid-mediated penicillinase from Streptococcus faecalis suggest a staphylococcal origin.来自粪肠球菌的质粒介导青霉素酶的体外研究表明其起源于葡萄球菌。
J Clin Invest. 1986 Jan;77(1):289-93. doi: 10.1172/JCI112289.
5
Activities and time-kill studies of selected penicillins, beta-lactamase inhibitor combinations, and glycopeptides against Enterococcus faecalis.所选青霉素、β-内酰胺酶抑制剂组合及糖肽类药物对粪肠球菌的活性及杀菌时间研究
Antimicrob Agents Chemother. 1998 Apr;42(4):857-61. doi: 10.1128/AAC.42.4.857.
6
Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.可转移的β-内酰胺酶。粪肠球菌体外青霉素耐药的一种新机制。
J Clin Invest. 1983 Sep;72(3):1168-71. doi: 10.1172/JCI111042.
7
Possible prevention of in vitro selection of resistant Streptococcus pneumoniae by beta-lactamase inhibitors.β-内酰胺酶抑制剂对肺炎链球菌体外耐药性选择的可能预防作用。
Eur J Clin Microbiol Infect Dis. 1994 Dec;13(12):1058-62. doi: 10.1007/BF02111828.
8
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with ampicillin and broad-spectrum penicillins against defined beta-lactamase-producing aerobic gram-negative bacilli.β-内酰胺酶抑制剂YTR 830、克拉维酸和舒巴坦与氨苄西林及广谱青霉素联合应用对特定产β-内酰胺酶需氧革兰氏阴性杆菌的比较活性
Antimicrob Agents Chemother. 1986 Jun;29(6):980-5. doi: 10.1128/AAC.29.6.980.
9
Time-kill kinetic studies of ampicillin/sulbactam for beta-lactamase-producing enterococci.
Diagn Microbiol Infect Dis. 1991 Nov-Dec;14(6):495-9. doi: 10.1016/0732-8893(91)90005-z.
10
The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins.β-内酰胺酶在葡萄球菌对耐青霉素酶青霉素和头孢菌素耐药性中的作用。
J Clin Microbiol. 1986 May;23(5):832-9. doi: 10.1128/jcm.23.5.832-839.1986.

引用本文的文献

1
Genetic diversity among Enterococcus faecalis.屎肠球菌的遗传多样性。
PLoS One. 2007 Jul 4;2(7):e582. doi: 10.1371/journal.pone.0000582.
2
Resistant enterococci--mechanisms, laboratory detection and control in hospitals.耐万古霉素肠球菌——医院中的机制、实验室检测与控制
J Clin Pathol. 1996 Sep;49(9):700-3. doi: 10.1136/jcp.49.9.700.
3
Mobilization of the penicillinase gene in Enterococcus faecalis.粪肠球菌中青霉素酶基因的转移
Antimicrob Agents Chemother. 1993 May;37(5):1187-9. doi: 10.1128/AAC.37.5.1187.
4
Molecular characterization of highly gentamicin-resistant Enterococcus faecalis isolates lacking high-level streptomycin resistance.缺乏高水平链霉素耐药性的高庆大霉素耐药粪肠球菌分离株的分子特征分析
Antimicrob Agents Chemother. 1993 Jan;37(1):134-7. doi: 10.1128/AAC.37.1.134.
5
Tn924, a chromosome-borne transposon encoding high-level gentamicin resistance in Enterococcus faecalis.Tn924，一种存在于粪肠球菌染色体上的转座子，其编码对庆大霉素的高水平耐药性。
Antimicrob Agents Chemother. 1994 May;38(5):1152-6. doi: 10.1128/AAC.38.5.1152.
6
Endocarditis caused by relatively penicillin-resistant Stomatococcus mucilaginosus.由相对耐青霉素的粘性口腔球菌引起的心内膜炎。
J Clin Microbiol. 1989 Jan;27(1):215-6. doi: 10.1128/jcm.27.1.215-216.1989.
7
Enterococci highly resistant to penicillin and ampicillin: an emerging clinical problem?对青霉素和氨苄西林高度耐药的肠球菌：一个新出现的临床问题？
J Clin Microbiol. 1989 Sep;27(9):2091-5. doi: 10.1128/jcm.27.9.2091-2095.1989.
8
Susceptibility of enterococci and epidemiology of enterococcal infection in the 1980s.20世纪80年代肠球菌的易感性及肠球菌感染的流行病学。
Epidemiol Infect. 1989 Dec;103(3):403-13. doi: 10.1017/s0950268800030806.
9
Treatment of experimental endocarditis caused by a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin.由对庆大霉素具有高水平耐药性的产β-内酰胺酶粪肠球菌菌株引起的实验性心内膜炎的治疗。
Antimicrob Agents Chemother. 1989 Jul;33(7):1019-22. doi: 10.1128/AAC.33.7.1019.
10
Susceptibility and bactericidal activity studies of four beta-lactamase-producing enterococci.四种产β-内酰胺酶肠球菌的药敏及杀菌活性研究
Antimicrob Agents Chemother. 1989 Feb;33(2):251-3. doi: 10.1128/AAC.33.2.251.

本文引用的文献

1
Transfer of resistance plasmids from Staphylococcus epidermidis to Staphylococcus aureus: evidence for conjugative exchange of resistance.耐药质粒从表皮葡萄球菌向金黄色葡萄球菌的转移：耐药性接合交换的证据。
J Bacteriol. 1983 Feb;153(2):627-34. doi: 10.1128/jb.153.2.627-634.1983.
2
Use of agarose gel electrophoresis of plasmid deoxyribonucleic acid to fingerprint gram-negative bacilli.利用质粒脱氧核糖核酸的琼脂糖凝胶电泳对革兰氏阴性杆菌进行指纹图谱分析。
J Clin Microbiol. 1981 Jun;13(6):1105-8. doi: 10.1128/jcm.13.6.1105-1108.1981.
3
Evaluation of a rapid system for species identification of alpha-hemolytic streptococci.一种用于α-溶血性链球菌菌种鉴定的快速系统的评估
J Clin Microbiol. 1982 Sep;16(3):521-4. doi: 10.1128/jcm.16.3.521-524.1982.
4
Plasmid content of Streptococcus faecalis strain 39-5 and identification of a pheromone (cPD1)-induced surface antigen.粪肠球菌39-5菌株的质粒含量及一种信息素（cPD1）诱导的表面抗原的鉴定。
J Gen Microbiol. 1983 Apr;129(4):1207-15. doi: 10.1099/00221287-129-4-1207.
5
Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.可转移的β-内酰胺酶。粪肠球菌体外青霉素耐药的一种新机制。
J Clin Invest. 1983 Sep;72(3):1168-71. doi: 10.1172/JCI111042.
6
High-level resistance to gentamicin in clinical isolates of enterococci.肠球菌临床分离株对庆大霉素的高水平耐药性。
J Infect Dis. 1983 Apr;147(4):751-7. doi: 10.1093/infdis/147.4.751.
7
Antibiotic synergism of enterococci. Relation to inhibitory concentrations.肠球菌的抗生素协同作用。与抑菌浓度的关系。
Arch Intern Med. 1970 Aug;126(2):255-9.
8
Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.一种使用显色头孢菌素底物检测β-内酰胺酶的新方法。
Antimicrob Agents Chemother. 1972 Apr;1(4):283-8. doi: 10.1128/AAC.1.4.283.
9
beta-Lactamase production in experimental endocarditis due to aminoglycoside-resistant Streptococcus faecalis.耐氨基糖苷类粪肠球菌所致实验性心内膜炎中β-内酰胺酶的产生
J Infect Dis. 1987 Jun;155(6):1226-32. doi: 10.1093/infdis/155.6.1226.
10
Heterogeneity of plasmids determining high-level resistance to gentamicin in clinical isolates of Streptococcus faecalis.粪肠球菌临床分离株中决定对庆大霉素高水平耐药性的质粒异质性。
Antimicrob Agents Chemother. 1986 Jul;30(1):78-81. doi: 10.1128/AAC.30.1.78.

两种产青霉素酶粪肠球菌（肠球菌）菌株的特性鉴定与比较。

Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis.

作者信息

Patterson J E, Masecar B L, Zervos M J

机构信息

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

出版信息

Antimicrob Agents Chemother. 1988 Jan;32(1):122-4. doi: 10.1128/AAC.32.1.122.

DOI:10.1128/AAC.32.1.122
PMID:3126703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172110/
Abstract

We identified two beta-lactamase-positive enterococci. One strain was high-level (MIC, greater than 2,000 microgram/ml) gentamicin resistant; the other was not (MIC, 12.5 microgram/ml). beta-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by beta-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.

摘要

我们鉴定出两株β-内酰胺酶阳性肠球菌。一株对庆大霉素高水平耐药（最低抑菌浓度，大于2000微克/毫升）；另一株则否（最低抑菌浓度，12.5微克/毫升）。两株菌的β-内酰胺酶产生均由染色体外介导，且两株菌均显示β-内酰胺酶抑制剂可逆转接种量效应。缺乏高水平庆大霉素耐药性的菌株在青霉素、克拉维酸和庆大霉素联合使用时表现出协同杀菌作用。