Ocsel Hakan, Teke Zafer, Sacar Mustafa, Kabay Burhan, Duzcan S Ender, Kara Inci Gokalan
Department of Plastic and Reconstructive Surgery, School of Medicine, Pamukkale University, Denizli, Turkey.
J Invest Surg. 2012 Aug;25(4):262-70. doi: 10.3109/08941939.2011.639847.
The objective of the present study was to assess the effects of oriental sweet gum (Liquidambar orientalis Mill.) storax on partial-thickness and full-thickness wounds compared to conventional wound dressings in a porcine model.
Six young Yorkshire pigs were used. Sixteen square excisional wounds measuring 3 × 3 cm were performed per animal. The wounds were allocated to one of the four treatment modalities: storax, hydrocolloid dressing, silver sulfadiazine, and control groups. Partial-thickness wounds were created in two pigs, and tissue samples were harvested on days 4 and 8, respectively. Full-thickness wounds were created in four pigs, and tissue samples were taken on days 4, 8, 14, and 21, respectively. Histologically, all wounds were examined for re-epithelialization and granulation tissue formation. Tissue hydroxyproline content and wound contraction areas were measured.
In storax-applied group, there was a greater depth of granulation tissue at 4 and 8 days compared to all other groups (p < .0125), and there was a faster re-epithelialization at 21 days compared to both hydrocolloid dressing and control groups in full-thickness wounds (p < .0125). Tissue hydroxyproline content and wound contraction did not differ significantly between the groups.
The results of this study indicate that topical application of storax enhanced both re-epithelialization and granulation tissue formation in full-thickness wounds. Further studies are indicated in this important area of wound healing research to evaluate the clinical efficacy of this storax and search for the mechanisms that explain its effects.
本研究的目的是在猪模型中，评估与传统伤口敷料相比，东方香脂（Liquidambar orientalis Mill.）苏合香对部分厚度和全层伤口的影响。
使用6只年轻的约克夏猪。每只动物制作16个3×3厘米的方形切除伤口。伤口被分配到四种治疗方式之一：苏合香、水胶体敷料、磺胺嘧啶银和对照组。在两只猪身上制造部分厚度伤口，分别在第4天和第8天采集组织样本。在四只猪身上制造全层伤口，分别在第4天、第8天、第14天和第21天采集组织样本。组织学上，检查所有伤口的再上皮化和肉芽组织形成情况。测量组织羟脯氨酸含量和伤口收缩面积。
与所有其他组相比，在第4天和第8天，应用苏合香的组肉芽组织深度更大（p < 0.0125），在全层伤口中，与水胶体敷料组和对照组相比，在第21天再上皮化更快（p < 0.0125）。各组之间组织羟脯氨酸含量和伤口收缩没有显著差异。
本研究结果表明，局部应用苏合香可促进全层伤口的再上皮化和肉芽组织形成。在伤口愈合研究的这一重要领域，需要进一步研究以评估这种苏合香的临床疗效，并寻找解释其作用的机制。
