Xu Zhuo, Lu Danni, Yuan Jianmei, Ren Mihong, Ma Rong, Xie Qian, Li Yong, Li Jinxiu, Wang Jian
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2021 Nov 30;12:785598. doi: 10.3389/fphar.2021.785598. eCollection 2021.
In recent years, the incidence and mortality of cardio-cerebrovascular diseases have been increasing year by year, which has become global burden and challenge. Based on the holistic thinking of "brain disease affects the heart" and "heart disease affects the brain," as well as the characteristics of multi-target and multi-path effects of Chinese medicine, Chinese medicine is more advantageous in the treatment of cardio-cerebrovascular diseases. As a botanical medicine, storax is known for its resuscitation, filth avoidance and pain-relieving effects in the treatment of cardio-cerebrovascular diseases. By reviewing and collating the relevant domestic and international literature in the past 10 years, we have sorted out an overview of the medicinal parts, traditional uses and chemical composition of storax. For the first time, based on the idea of "cerebral and cardiac simultaneous treatment," the pharmacological activities and mechanisms of heart and brain protection of storax for treating cardio-cerebrovascular diseases were summarized and analyzed, showing that storax has the pharmacological effects of anti-cerebral ischemia, regulation of blood-brain barrier, bidirectional regulation of the central nervous system, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis and anti-platelet aggregation. It mainly exerts its protective effects on the brain and heart through mechanisms such as inhibition of inflammatory immune factors, anti-oxidative stress, anti-apoptosis, pro-neovascularization and regulation of NO release. On the basis of the current findings and limitations, the future research strategies and perspectives of storax are proposed, with a view to providing a reference for further application and development of this medicine, as well as contributing new thoughts and visions for the clinical application of "treating brain-heart synchronously".
近年来，心脑血管疾病的发病率和死亡率逐年上升，已成为全球性负担和挑战。基于“脑病及心”“心病及脑”的整体思维，以及中医药多靶点、多途径作用的特点，中医药在治疗心脑血管疾病方面更具优势。苏合香作为一种植物药，在治疗心脑血管疾病方面以其开窍、辟秽、止痛之功效而闻名。通过回顾和整理过去10年国内外相关文献，梳理了苏合香的药用部位、传统用途及化学成分概况。首次基于“脑心同治”理念，总结分析了苏合香治疗心脑血管疾病的心脏和脑保护药理活性及作用机制，表明苏合香具有抗脑缺血、调节血脑屏障、双向调节中枢神经系统、抗心肌缺血、抗心律失常、抗血栓及抗血小板聚集等药理作用。其主要通过抑制炎性免疫因子、抗氧化应激、抗凋亡、促血管新生及调节一氧化氮释放等机制发挥对脑和心脏的保护作用。基于目前的研究结果及局限性，提出了苏合香未来的研究策略与展望，以期为该药的进一步应用与开发提供参考，也为“脑心同治”的临床应用贡献新的思路与视野。
