Igdır Public Hospital, Department of Plastic and Reconstructive Surgery, Igdır, Turkey.
Burns. 2013 Mar;39(2):320-5. doi: 10.1016/j.burns.2012.06.015. Epub 2012 Jul 31.
The zone of stasis, the encircling area of the zone of coagulation, is a critical area which determines the depth and width of the necrosis in burns. Many agents were proposed to salvage the zone of stasis. Due to the known preventive and therapeutic effects of N-acetylcysteine on hepatotoxicity, nephrotoxicity, pulmonary injury, and multiple organ failure in humans, the effect of N-acetylcysteine on saving the zone of stasis was investigated in this experimental study. The effects of N-acetylcysteine administration via oral or intraperitoneal route was compared in a rat comb-burn model. The extent of burn wounds was evaluated by photography and planimetry in the groups. Additionally, skin samples were obtained to analyze malondialdehyde levels to see the antioxidant effect of N-acetylcysteine. In control group (no treatment), the burn areas went to near total necrosis. In intraperitoneal and oral treatment groups, skin survival occurred in the interspace area of the comb. There was no difference between the groups in terms of MDA concentrations. In conclusion, this study showed us the possible saving effect of N-acetylcysteine on the zone of stasis. N-acetylcysteine may be used in the cases of severe burns, not only for its effects on wound healing but also the systemic effects of the drug.
缺血区，即凝固区的环绕区域，是决定烧伤坏死深度和宽度的关键区域。许多药物被提出用于挽救缺血区。由于 N-乙酰半胱氨酸在人类中对肝毒性、肾毒性、肺损伤和多器官衰竭具有已知的预防和治疗作用，因此在这项实验研究中研究了 N-乙酰半胱氨酸对挽救缺血区的作用。通过口服或腹腔内途径给予 N-乙酰半胱氨酸的效果在大鼠梳状烧伤模型中进行了比较。通过摄影和平面测量评估了各组烧伤创面的程度。此外，还获得了皮肤样本以分析丙二醛水平，以观察 N-乙酰半胱氨酸的抗氧化作用。在对照组（未治疗）中，烧伤区域几乎全部坏死。在腹腔内和口服治疗组中，梳子间隙区域的皮肤存活。各组间 MDA 浓度无差异。总之，这项研究表明 N-乙酰半胱氨酸对缺血区可能具有挽救作用。N-乙酰半胱氨酸不仅可因其对伤口愈合的作用，还可因其药物的全身作用而用于严重烧伤的情况。
