Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
J Acad Nutr Diet. 2012 Nov;112(11):1822-7. doi: 10.1016/j.jand.2012.06.008. Epub 2012 Jul 31.
Diet may represent a modifiable prostate cancer risk factor, but a vegetable-based prostate-healthy diet is a major change for most men. We used a ratio of animal to vegetable proteins (A:V) to evaluate whether a comprehensive dietary change was self-sustaining following completion of 11 weekly dietary and cooking classes that integrated mindfulness training. Thirty-six men with recurring prostate cancer were randomized to the intervention or wait-list control. Assessments were at baseline, 3 months, and 6 months. Of 17 men randomized to the intervention, 14 completed the requirements. Nineteen were randomized to control and 17 completed requirements. Compared with controls, a significant postintervention (3 months) decrease in A:V in the intervention group (P=0.01) was self-maintained 3 months postintervention (P=0.049). At each assessment, A:V was correlated with lycopene, fiber, saturated fat, and dietary cholesterol, four dietary components linked to clinically relevant outcomes in prostate cancer. Change in A:V was also significantly correlated with changes in fiber, saturated fat, and dietary cholesterol intake. Participants reported regular mindfulness training practice, and there was a significant correlation between mindfulness training practice and changes in both initiation and maintenance of the change in A:V. These pilot results provide encouraging evidence for the feasibility of a dietary program that includes mindfulness training in supporting dietary change for men with recurrent prostate cancer and invite further study to explore the possible role of mindfulness training as a means of supporting both initiation of dietary changes and maintenance of those changes over time.
饮食可能是前列腺癌的一个可改变的风险因素，但对于大多数男性来说，采用以植物性食物为主的前列腺健康饮食是一个重大的改变。我们使用动物蛋白与植物蛋白的比例（A:V）来评估在完成 11 周的饮食和烹饪课程（整合了正念训练）后，全面的饮食改变是否能够持续。36 名患有复发性前列腺癌的男性被随机分配到干预组或候补对照组。评估在基线、3 个月和 6 个月时进行。在随机分配到干预组的 17 名男性中，有 14 名完成了要求。19 名被随机分配到对照组，其中 17 名完成了要求。与对照组相比，干预组在干预后（3 个月）的 A:V 显著下降（P=0.01），并在干预后 3 个月（P=0.049）持续下降。在每次评估时，A:V 与番茄红素、纤维、饱和脂肪和饮食胆固醇呈正相关，这四种饮食成分与前列腺癌的临床相关结果有关。A:V 的变化也与纤维、饱和脂肪和饮食胆固醇的摄入变化显著相关。参与者报告了定期的正念训练实践，并且正念训练实践与 A:V 的起始和维持变化之间存在显著相关性。这些初步结果为包括正念训练的饮食计划在支持复发性前列腺癌男性的饮食改变方面的可行性提供了令人鼓舞的证据，并邀请进一步研究探索正念训练作为支持饮食改变的发起和随着时间的推移维持这些改变的可能作用。
