• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

种族和民族对癌症生物学的影响。

The influence of race and ethnicity on the biology of cancer.

机构信息

The Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033-0804, USA.

出版信息

Nat Rev Cancer. 2012 Sep;12(9):648-53. doi: 10.1038/nrc3341. Epub 2012 Aug 2.

DOI:10.1038/nrc3341
PMID:22854838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3677949/
Abstract

It is becoming clear that some of the differences in cancer risk, incidence and survival among people of different racial and ethnic backgrounds can be attributed to biological factors. However, identifying these factors and exploiting them to help eliminate cancer disparities has proved challenging. With this in mind, we asked four scientists for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important emerging area of research.

摘要

很明显,不同种族和民族背景的人群在癌症风险、发病率和生存率方面的一些差异可以归因于生物学因素。然而,确定这些因素并利用它们来帮助消除癌症差异一直具有挑战性。考虑到这一点,我们询问了四位科学家,让他们谈谈这一重要新兴研究领域最关键的进展、挑战以及未来前景。

相似文献

1
The influence of race and ethnicity on the biology of cancer.种族和民族对癌症生物学的影响。
Nat Rev Cancer. 2012 Sep;12(9):648-53. doi: 10.1038/nrc3341. Epub 2012 Aug 2.
2
Disparities in cancer care among racial and ethnic minorities.种族和少数民族在癌症护理方面的差异。
Oncology (Williston Park). 2006 Sep;20(10):1256-61; discussion 1261, 1265, 1268-70.
3
Cancer survival disparities by race/ethnicity and socioeconomic status in New Jersey.新泽西州不同种族/族裔和社会经济地位的癌症生存率差异
J Health Care Poor Underserved. 2010 Feb;21(1):144-60. doi: 10.1353/hpu.0.0263.
4
Does socioeconomic disparity in cancer incidence vary across racial/ethnic groups?癌症发病率的社会经济差异是否因种族/族裔群体而异?
Cancer Causes Control. 2010 Oct;21(10):1721-30. doi: 10.1007/s10552-010-9601-y. Epub 2010 Jun 22.
5
Genomics and Cancer Disparities: The Justice and Power of Inclusion.基因组学与癌症差异:包容的正义与力量
Cancer Discov. 2021 Apr;11(4):805-809. doi: 10.1158/2159-8290.CD-21-0225.
6
Cancer in U.S. ethnic and racial minority populations.美国少数族裔和种族群体中的癌症。
Annu Rev Nurs Res. 2004;22:217-63.
7
Palliative care experiences of adult cancer patients from ethnocultural groups: a qualitative systematic review protocol.不同种族文化群体成年癌症患者的姑息治疗体验:一项定性系统评价方案
JBI Database System Rev Implement Rep. 2015 Jan;13(1):99-111. doi: 10.11124/jbisrir-2015-1809.
8
Racial/ethnic disparities in human DNA methylation.人类DNA甲基化中的种族/民族差异。
Biochim Biophys Acta. 2014 Aug;1846(1):258-62. doi: 10.1016/j.bbcan.2014.07.001. Epub 2014 Jul 10.
9
Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate.患者生存率和肿瘤突变负担的种族差异,以及肿瘤突变负担与癌症发病率之间的关系。
Sci Rep. 2017 Oct 20;7(1):13639. doi: 10.1038/s41598-017-13091-y.
10
Cancer disparities: unmet challenges in the elimination of disparities.癌症差异:消除差异方面未满足的挑战。
Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1809-14. doi: 10.1158/1055-9965.EPI-11-0628. Epub 2011 Jul 22.

引用本文的文献

1
Harnessing AI for Improved Detection and Classification of Pleural Effusion: Insights and Innovations.利用人工智能改进胸腔积液的检测与分类:见解与创新
Can Respir J. 2025 Aug 6;2025:2882255. doi: 10.1155/carj/2882255. eCollection 2025.
2
Characterizing neurofibromin 1-altered breast cancer through genomic, functional, and clinical analyses.通过基因组、功能和临床分析对神经纤维瘤蛋白1改变的乳腺癌进行特征描述。
Virchows Arch. 2025 Aug 14. doi: 10.1007/s00428-025-04218-y.
3
Shared genetic association between inflammatory bowel disease and acute myeloid leukemia: insights from mendelian randomization and transcriptomic analyses.炎症性肠病与急性髓系白血病之间的共同遗传关联:孟德尔随机化和转录组分析的见解
Inflamm Res. 2025 Apr 30;74(1):77. doi: 10.1007/s00011-025-02038-z.
4
Glucagon-like peptide 1 receptor agonists and cancer risk: advancing precision medicine through mechanistic understanding and clinical evidence.胰高血糖素样肽1受体激动剂与癌症风险:通过机制理解和临床证据推动精准医学发展
Biomark Res. 2025 Mar 27;13(1):50. doi: 10.1186/s40364-025-00765-3.
5
Overall Observed Survival of Female Breast, Cervical, Colorectal, and Prostate Cancers in Antigua and Barbuda, 2017-2021: Retrospective Data from Four Study Sites.2017 - 2021年安提瓜和巴布达女性乳腺癌、宫颈癌、结直肠癌和前列腺癌的总体观察生存率:来自四个研究地点的回顾性数据
Int J Environ Res Public Health. 2025 Feb 7;22(2):235. doi: 10.3390/ijerph22020235.
6
Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing.全外显子组测序揭示印度乳腺癌病例的体细胞突变全景
Sci Rep. 2024 Aug 12;14(1):18679. doi: 10.1038/s41598-024-65148-4.
7
Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients.西班牙裔/拉丁裔患者的遗传血统与根治性前列腺切除术结果
Front Oncol. 2024 Apr 3;14:1338250. doi: 10.3389/fonc.2024.1338250. eCollection 2024.
8
Fine-scale mapping of chromosome 9q22.33 identifies candidate causal variant in ovarian cancer.精细定位染色体 9q22.33 确定卵巢癌的候选因果变异。
PeerJ. 2024 Feb 14;12:e16918. doi: 10.7717/peerj.16918. eCollection 2024.
9
Association of survival with adjuvant chemotherapy in patients with stage IB gastric cancer: a multicentre, observational, cohort study.IB 期胃癌患者辅助化疗与生存的关联:一项多中心、观察性队列研究
Lancet Reg Health West Pac. 2024 Feb 12;45:101031. doi: 10.1016/j.lanwpc.2024.101031. eCollection 2024 Apr.
10
Association of germline variants with somatic variants in breast tumors in a genome-wide study.一项全基因组研究中乳腺癌肿瘤种系变异与体细胞变异的关联
medRxiv. 2023 Dec 6:2023.12.06.23299442. doi: 10.1101/2023.12.06.23299442.

本文引用的文献

1
Annual Report to the Nation on the status of cancer, 1975-2008, featuring cancers associated with excess weight and lack of sufficient physical activity.《1975-2008 年全国癌症报告:超重和缺乏足够身体活动相关癌症》
Cancer. 2012 May 1;118(9):2338-66. doi: 10.1002/cncr.27514. Epub 2012 Mar 28.
2
Cancer statistics, 2012.癌症统计数据,2012 年。
CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29. doi: 10.3322/caac.20138. Epub 2012 Jan 4.
3
Cancer stem cells: an evolving concept.癌症干细胞:一个不断发展的概念。
Nat Rev Cancer. 2012 Jan 12;12(2):133-43. doi: 10.1038/nrc3184.
4
The mystery of missing heritability: Genetic interactions create phantom heritability.遗传力缺失之谜:基因相互作用产生了幽灵遗传力。
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8. doi: 10.1073/pnas.1119675109. Epub 2012 Jan 5.
5
Assessing the clinical role of genetic markers of early-onset prostate cancer among high-risk men enrolled in prostate cancer early detection.评估前列腺癌早期检测项目中高危男性的早发性前列腺癌遗传标志物的临床作用。
Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):53-60. doi: 10.1158/1055-9965.EPI-11-0727. Epub 2011 Dec 5.
6
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.TERT-CLPTM1L 基因座的常见变异与雌激素受体阴性乳腺癌相关。
Nat Genet. 2011 Oct 30;43(12):1210-4. doi: 10.1038/ng.985.
7
A decade of exploring the cancer epigenome - biological and translational implications.一个探索癌症表观基因组的十年 - 生物学和转化意义。
Nat Rev Cancer. 2011 Sep 23;11(10):726-34. doi: 10.1038/nrc3130.
8
Multi-ethnic studies in complex traits.复杂性状的多民族研究。
Hum Mol Genet. 2011 Oct 15;20(R2):R206-13. doi: 10.1093/hmg/ddr386. Epub 2011 Sep 2.
9
Demographic history and rare allele sharing among human populations.人口历史与人类群体中的罕见等位基因共享。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-8. doi: 10.1073/pnas.1019276108. Epub 2011 Jul 5.
10
Current status of genome-wide association studies in cancer.癌症全基因组关联研究的现状。
Hum Genet. 2011 Jul;130(1):59-78. doi: 10.1007/s00439-011-1030-9. Epub 2011 Jun 16.