Department of Infectious Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Sci Rep. 2012;2:548. doi: 10.1038/srep00548. Epub 2012 Jul 31.
hOGG1 encodes a DNA repair enzyme responsible for the excision of reactive oxygen species (ROS) in damaged DNA. Previous studies have obtained inconsistent results. To validate the association between the hOGG1Ser326Cys polymorphism and lung cancer risk, we performed an updated meta-analysis of 20 studies (8739 cases and 10385 controls) using STATA version 11.1. With this approach, we tested the overall and subgroup association between the SNP and lung cancer susceptibility stratified by ethnicity, control sources, cell histotypes, and smoking status. We demonstrated a novel, significant correlation between the hOGG1 Ser326Cys polymorphism and increased lung cancer susceptibility in Caucasians. Our findings indicate a need for larger-scale studies to verify the association of this SNP with lung cancer risk in Caucasians.
hOGG1 编码一种 DNA 修复酶，负责切除受损 DNA 中的活性氧（ROS）。先前的研究得到了不一致的结果。为了验证 hOGG1Ser326Cys 多态性与肺癌风险之间的关联，我们使用 STATA 版本 11.1 对 20 项研究（8739 例病例和 10385 例对照）进行了更新的荟萃分析。通过这种方法，我们检测了 SNP 与肺癌易感性之间的总体和亚组关联，并按种族、对照来源、细胞组织类型和吸烟状况进行了分层。我们证明了 hOGG1Ser326Cys 多态性与高加索人群肺癌易感性增加之间存在新的、显著的相关性。我们的研究结果表明，需要进行更大规模的研究来验证该 SNP 与高加索人群肺癌风险的关联。
