Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, P.O. Box 208114, Bass 236A, New Haven, CT 06520-8114, USA.
Trends Cell Biol. 2012 Oct;22(10):509-14. doi: 10.1016/j.tcb.2012.07.003. Epub 2012 Jul 31.
Herpesvirus capsids traverse the nuclear envelope (NE) by utilizing an unusual export pathway termed nuclear egress. In this process, the viral capsid is delivered into the perinuclear space (PNS), producing a vesicular intermediate after fission. After fusion with the outer nuclear membrane (ONM), the naked capsid is released into the cytosol. A recent study now suggests that this pathway might be an endogenous cellular pathway, co-opted by viruses, that serves to transport cellular cargo exceeding the size limit imposed by the nuclear pore complex (NPC). We propose that one function of this pathway is to transport nuclear protein aggregates to the cytosolic autophagy machinery. Our model has implications for our understanding of laminopathies and related diseases affecting proteins residing at the inner nuclear membrane (INM) and nuclear lamina.
疱疹病毒衣壳通过利用一种称为核输出的不寻常出口途径穿过核膜（NE）。在这个过程中，病毒衣壳被递送到核周空间（PNS），在分裂后产生囊泡中间体。与外核膜（ONM）融合后，裸露的衣壳被释放到细胞质中。最近的一项研究表明，该途径可能是一种被病毒采用的内源性细胞途径，用于运输超过核孔复合体（NPC）所施加的大小限制的细胞货物。我们提出，该途径的一个功能是将核蛋白聚集体运输到细胞质自噬机制中。我们的模型对于理解影响位于内核膜（INM）和核层的蛋白质的核纤层病和相关疾病具有重要意义。
