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颈椎间盘突出症和神经根炎的慢性疼痛管理,采用透视颈椎间硬膜外注射。

Management of chronic pain of cervical disc herniation and radiculitis with fluoroscopic cervical interlaminar epidural injections.

机构信息

Pain Management Center of Paducah, Paducah, KY, USA.

出版信息

Int J Med Sci. 2012;9(6):424-34. doi: 10.7150/ijms.4444. Epub 2012 Jul 23.

Abstract

STUDY DESIGN

A randomized, double-blind, active controlled trial.

OBJECTIVE

To evaluate the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids in the management of chronic neck pain and upper extremity pain in patients with disc herniation and radiculitis.

SUMMARY OF BACKGROUND DATA

Epidural injections in managing chronic neck and upper extremity pain are commonly employed interventions. However, their long-term effectiveness, indications, and medical necessity, of their use and their role in various pathologies responsible for persistent neck and upper extremity pain continue to be debated, even though, neck and upper extremity pain secondary to disc herniation and radiculitis, is described as the common indication. There is also paucity of high quality literature.

METHODS

One-hundred twenty patients were randomly assigned to one of 2 groups: Group I patients received cervical interlaminar epidural injections of local anesthetic (lidocaine 0.5%, 5 mL); Group II patients received 0.5% lidocaine, 4 mL, mixed with 1 mL of nonparticulate betamethasone. Primary outcome measure was ≥ 50 improvement in pain and function. Outcome assessments included Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), opioid intake, employment, and changes in weight.

RESULTS

Significant pain relief and functional status improvement (≥ 50%) was demonstrated in 72% of patients who received local anesthetic only and 68% who received local anesthetic and steroids. In the successful group of participants, significant improvement was illustrated in 77% in local anesthetic group and 82% in local anesthetic with steroid group.

CONCLUSIONS

Cervical interlaminar epidural injections with or without steroids may provide significant improvement in pain and function for patients with cervical disc herniation and radiculitis.

摘要

研究设计

一项随机、双盲、阳性对照试验。

目的

评估颈椎间硬膜外注射局部麻醉药与或不与类固醇治疗椎间盘突出症和神经根炎患者慢性颈痛和上肢痛的疗效。

背景资料概要

硬膜外注射在治疗慢性颈痛和上肢痛方面是常用的干预措施。然而,它们的长期疗效、适应证和使用的医学必要性,以及它们在导致持续性颈痛和上肢痛的各种病变中的作用仍在争论中,尽管颈痛和上肢痛继发于椎间盘突出症和神经根炎,被认为是常见的适应证。而且,高质量文献也很少。

方法

120 名患者被随机分配到两组之一:I 组患者接受颈椎间硬膜外注射局部麻醉药(利多卡因 0.5%,5 毫升);II 组患者接受 0.5%利多卡因 4 毫升,混合 1 毫升非颗粒倍他米松。主要观察指标为疼痛和功能改善≥50%。评估结果包括数字评分量表(NRS)、Oswestry 残疾指数(ODI)、阿片类药物摄入量、就业情况以及体重变化。

结果

仅接受局部麻醉的患者中 72%和接受局部麻醉和类固醇的患者中 68%表现出明显的疼痛缓解和功能状态改善(≥50%)。在成功组患者中,局部麻醉组有 77%、局部麻醉加类固醇组有 82%的患者显著改善。

结论

颈椎间硬膜外注射局部麻醉药与或不与类固醇可能为颈椎间盘突出症和神经根炎患者的疼痛和功能提供显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/3410361/7060cb651135/ijmsv09p0424g01.jpg

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