Epstein Aaron, Wing Deborah A, Ouzounian Joseph G, Miller David A, Lee Richard H
Department of Obstetrics and Gynecology, University of California, Irvine, Orange, CA 90033, USA.
J Matern Fetal Neonatal Med. 2012 Dec;25(12):2588-90. doi: 10.3109/14767058.2012.713054. Epub 2012 Aug 24.
An association between Helicobacter pylori (H. pylori) and thrombocytopenia has been demonstrated in the literature in a non-pregnant population. The purpose of this study was to determine whether or not there is a similar association in the third trimester of pregnancy in a Hispanic population.
This is a secondary analysis of 82 pregnant Hispanic women with and without hyperemesis gravidarum who underwent serologic evaluation for H. pylori IgG. Results of complete blood counts obtained in the third trimester were analysed for thrombocytopenia.
Of the 82 subjects who had H. pylori testing, 54 subjects had both serum H. pylori IgG results and third trimester platelet levels. The prevalence of thrombocytopenia was 11.1% (6/54). Thirty-six subjects were seropositive for H. pylori IgG and 18 subjects were seronegative. Of the 36 subjects who were H. pylori seropositive, four (11.1%) developed thrombocytopenia compared to three of 18 (16.7%) H. pylori seronegative subjects (P = 0.67). There was no difference between the groups in their mean platelet values (205 K/cu mm vs. 212 K/cu mm, P = 0.69).
In this limited study, we found no association between H. pylori and thrombocytopenia in the pregnant Hispanic population.
文献已证实在非妊娠人群中幽门螺杆菌（H. pylori）与血小板减少之间存在关联。本研究的目的是确定在西班牙裔人群的妊娠晚期是否存在类似关联。
这是一项对82名患有或未患有妊娠剧吐的西班牙裔孕妇进行的二次分析，这些孕妇接受了幽门螺杆菌IgG的血清学评估。分析妊娠晚期全血细胞计数结果以检测血小板减少情况。
在82名接受幽门螺杆菌检测的受试者中，54名受试者同时有血清幽门螺杆菌IgG结果和妊娠晚期血小板水平。血小板减少的患病率为11.1%（6/54）。三十六名受试者幽门螺杆菌IgG血清学阳性，十八名受试者血清学阴性。在36名幽门螺杆菌血清学阳性的受试者中，四名（11.1%）出现血小板减少，而18名幽门螺杆菌血清学阴性受试者中有三名（16.7%）出现血小板减少（P = 0.67）。两组的平均血小板值无差异（205 K/立方毫米对212 K/立方毫米，P = 0.69）。
在这项有限的研究中，我们发现在西班牙裔妊娠人群中幽门螺杆菌与血小板减少之间无关联。
