海洋来源 ω-3 脂肪酸对静息和应激时全身血液动力学的影响：剂量反应研究。
Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.
机构信息
Departments of Nutritional Sciences (ACS, PMKE, SGW) and Biobehavioral Health (SGW), Pennsylvania State University, University Park, PA 16802, USA.
出版信息
Ann Behav Med. 2012 Dec;44(3):301-8. doi: 10.1007/s12160-012-9393-2.
BACKGROUND
Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms.
PURPOSE
We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks.
METHODS
This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults.
RESULTS
Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids.
CONCLUSIONS
High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).
背景
一些研究表明，ω-3 脂肪酸可降低心率（HR）和血压（BP），但剂量反应研究较为罕见，其潜在机制知之甚少。
目的
我们研究了每天 0.85 克二十碳五烯酸（EPA）+二十二碳六烯酸（DHA）（低剂量）和 3.4 克 EPA+DHA（高剂量）对静息、言语和足部冷加压任务期间心率和全身血液动力学的影响。
方法
这是一项剂量反应、安慰剂对照、双盲、随机、交叉试验（8 周治疗，6 周洗脱期），纳入了 26 名成年人。
结果
在整个测试过程中，心率呈剂量依赖性降低。高剂量可降低血压和每搏量，并增加射血前期。血压的降低与红细胞中 ω-3 脂肪酸的增加有关。
结论
高剂量长链 ω-3 脂肪酸可降低静息和应激时的血压和心率。这些发现表明，高危人群可能会通过增加 ω-3 脂肪酸的摄入而获益。该试验在 ClinicalTrials.gov 注册（NCT00504309）。
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