Laboratorio di Biomateriali, Bioengineering Department and UdR INSTM Milano Politecnico, Politecnico di Milano, Milano - Italy .
J Appl Biomater Funct Mater. 2012 Sep 27;10(2):67-81. doi: 10.5301/JABFM.2012.9418.
Natural polymers, because of their biocompatibility, availability, and physico-chemical properties have been the materials of choice for the fabrication of injectable hydrogels for regenerative medicine. In particular, they are appealing materials for delivery systems and provide sustained and controlled release of drugs, proteins, gene, cells, and other active biomolecules immobilized.In this work, the use of hydrogels obtained from natural source polymers as cell delivery systems is discussed. These materials were investigated for the repair of cartilage, bone, adipose tissue, intervertebral disc, neural, and cardiac tissue. Papers from the last ten years were considered, with a particular focus on the advances of the last five years. A critical discussion is centered on new perspectives and challenges in the regeneration of specific tissues, with the aim of highlighting the limits of current systems and possible future advancements.
天然聚合物由于其生物相容性、可用性和物理化学性质，已成为可注射水凝胶再生医学制造的首选材料。特别是，它们是用于药物、蛋白质、基因、细胞和其他固定化生物活性分子的递送系统的有吸引力的材料，可提供药物的持续和控制释放。在这项工作中，讨论了将天然来源聚合物获得的水凝胶用作细胞递送系统。研究了这些材料在软骨、骨、脂肪组织、椎间盘、神经和心脏组织修复中的应用。考虑了过去十年的论文，特别关注过去五年的进展。重点围绕特定组织再生的新观点和挑战进行了批判性讨论，旨在突出当前系统的局限性和可能的未来进展。
