University of Bonn, LIMES Institute, Bonn, Germany.
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9176-80. doi: 10.1002/anie.201204174. Epub 2012 Aug 2.
A most able label: Labeled aptamers can be cross-linked to their target structures in a light-dependent and highly specific manner as a result of a new strategy termed aptamer-based affinity labeling (ABAL) of proteins. The aptamer-protein complexes can be enriched in vitro, from a cellular lysate and from the surface of living cells, opening new ways to study aptamer interactions in biological contexts.
通过一种新策略——基于适体的亲和标记（ABAL）的蛋白质，标记的适体可以以光依赖性和高度特异性的方式与它们的靶结构交联。适体-蛋白质复合物可以在体外、细胞裂解液中和活细胞表面进行富集，为在生物环境中研究适体相互作用开辟了新的途径。
