MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
J Psychiatr Res. 2012 Dec;46(12):1584-9. doi: 10.1016/j.jpsychires.2012.07.009. Epub 2012 Aug 4.
Research concerned with the association between stressful life events [SLEs] and bipolar disorder [BD] is inconsistent. Drawing on the unipolar depression literature, specific classifications of events (in particular, humiliation and loss events) seem to be especially important, while for anxiety disorders loss and danger events have been found to be pertinent. However, little or nothing is known about the relationship between such events and BD. The aim of the present investigation is to examine the association between danger and loss events and symptom exacerbation in BD. A total of 96 BD participants were interviewed using the Life Events and Difficulties Schedule [LEDS] at two time points: baseline and 4 month follow-up. Self-report and observer-rated symptom measures were administered at both interviews. The Beck Depression Inventory-Second Edition and the Montgomery Asberg Depression Rating Scale were used to measure depressive symptoms. The Self-Report Mania Inventory and Clinician-Administered Rating Scale for Mania were used to rate manic symptoms. Independent severe events, independent loss events and independent danger events were found to be significantly associated with worsening of depressive symptoms over an 8-month period. No significant associations were observed for manic symptoms. Specific relationships with different types of SLEs may explain previous discrepant findings concerning the relationship between SLEs and BD.
有关应激性生活事件（SLEs）与双相情感障碍（BD）之间关联的研究结果并不一致。借鉴单相抑郁文献，特定类型的事件（特别是羞辱和丧失事件）似乎尤为重要，而对于焦虑障碍，丧失和危险事件则与之相关。然而，人们对这些事件与 BD 之间的关系知之甚少。本研究旨在探讨危险和丧失事件与 BD 症状恶化之间的关系。共有 96 名 BD 患者在基线和 4 个月随访时两次接受生活事件和困难量表（LEDS）访谈。两次访谈均进行了自我报告和观察评定的症状测量。采用贝克抑郁量表第二版和蒙哥马利-阿斯伯格抑郁评定量表评估抑郁症状。自我报告躁狂量表和临床医生评定的躁狂量表用于评定躁狂症状。独立的严重事件、独立的丧失事件和独立的危险事件与 8 个月期间抑郁症状的恶化显著相关。躁狂症状则无显著相关性。与不同类型 SLEs 的特定关系可以解释之前 SLEs 与 BD 之间关系的不一致发现。
