Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Food Chem. 2012 Nov 15;135(2):356-61. doi: 10.1016/j.foodchem.2012.04.120. Epub 2012 May 1.
The effect of a yoghurt supplement containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536 on plasma lipids, lipid peroxidation and the faecal excretion of bile acids was examined in rats fed a cholesterol-enriched diet. After 8 weeks, the rats in the positive control (PC) group who were fed the cholesterol-enriched diet showed significant increases in plasma total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, and malondialdehyde (MDA). However, groups fed a cholesterol-enriched diet supplemented with yoghurt containing B. pseudocatenulatum G4 or B. longum BB536 had significantly lower plasma TC, LDL-C, very-low-density lipoprotein (VLDL) cholesterol, and MDA than had the PC group after 8 weeks of treatment. In addition, faecal excretion of bile acids was markedly increased in the rats fed the yoghurt containing B. pseudocatenulatum G4 or B. longum BB536 as compared to the PC and NC groups.
在给予富含胆固醇的饮食后，研究了含有双歧杆菌假长双歧杆菌 G4 或长双歧杆菌 BB536 的酸奶补充剂对大鼠血浆脂质、脂质过氧化和胆汁酸粪便排泄的影响。8 周后，给予富含胆固醇饮食的阳性对照组（PC）大鼠的血浆总胆固醇（TC）、低密度脂蛋白（LDL）胆固醇和丙二醛（MDA）显著增加。然而，与 PC 组相比，给予富含胆固醇饮食并补充含有双歧杆菌假长双歧杆菌 G4 或长双歧杆菌 BB536 的酸奶的大鼠在 8 周治疗后，血浆 TC、LDL-C、极低密度脂蛋白（VLDL）胆固醇和 MDA 明显降低。此外，与 PC 和 NC 组相比，给予含有双歧杆菌假长双歧杆菌 G4 或长双歧杆菌 BB536 的酸奶的大鼠粪便中胆汁酸排泄明显增加。
