未成熟粒细胞计数和幼稚髓细胞信息在新生儿败血症诊断中的预测价值。
The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis.
机构信息
Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria.
出版信息
Clin Chem Lab Med. 2012 Feb 23;50(8):1429-32. doi: 10.1515/cclm-2011-0656.
BACKGROUND
To determine the predictive value of the immature granulocyte count and the immature myeloid information in neonatal early onset sepsis we examined 133 blood samples of patients admitted to our neonatal intensive care unit.
METHODS
Measurements were performed using the Sysmex XE-2100, an automated hematological analyzer. Patients were divided into two groups: 1) symptomatic neonates with diagnosis of early onset sepsis; and 2) controls including asymptomatic neonates who were admitted because of prematurity, low birth weight, or delayed postnatal transition.
RESULTS
The number of immature granulocytes and the immature myeloid information were significantly elevated in neonates with early onset sepsis compared to controls (median 280/μL vs. 50/μL, p=0.049 and 639/μL vs. 89/μL, p<0.0001, respectively).
CONCLUSIONS
Automated determinations of immature granulocytes and immature myeloid information seem to be useful adjunctive methods in the diagnosis of neonatal early onset sepsis.
背景
为了确定幼稚粒细胞计数和幼稚髓细胞信息在新生儿早发性败血症中的预测价值，我们检测了 133 例入住新生儿重症监护病房患者的血液样本。
方法
使用Sysmex XE-2100 全自动血液分析仪进行测量。患者分为两组：1）有早发性败血症诊断症状的新生儿；2）对照组包括因早产、低出生体重或延迟产后过渡期而入院的无症状新生儿。
结果
与对照组相比，早发性败血症新生儿的幼稚粒细胞数和幼稚髓细胞信息明显升高（中位数 280/μL 与 50/μL，p=0.049 和 639/μL 与 89/μL，p<0.0001）。
结论
幼稚粒细胞和幼稚髓细胞信息的自动测定似乎是新生儿早发性败血症诊断的有用辅助方法。
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