Riond J L, Riviere J E
Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University.
J Vet Pharmacol Ther. 1990 Dec;13(4):404-7. doi: 10.1111/j.1365-2885.1990.tb00795.x.
Doxycycline serum concentration-time profiles and elimination half-lives in several species were evaluated by allometric techniques. Doxycycline elimination half-life increased with body weight. Interspecies scaling of total or free doxycycline serum concentration-time profiles was possible by use of Dedrick plots with the exception of doxycycline total concentrations in cats. The observed difference in cats was attributed to more extensive binding to plasma proteins.
通过异速生长技术评估了几种物种中多西环素的血清浓度-时间曲线和消除半衰期。多西环素的消除半衰期随体重增加而延长。除猫的多西环素总浓度外，使用德德里克图可以对总多西环素或游离多西环素的血清浓度-时间曲线进行种间标度。在猫身上观察到的差异归因于与血浆蛋白的结合更广泛。
