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用于放射免疫治疗的67铜的生产、分离及应用:综述

The production, separation, and use of 67Cu for radioimmunotherapy: a review.

作者信息

Smith Nicholas A, Bowers Delbert L, Ehst David A

机构信息

Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, IL 60439, USA.

出版信息

Appl Radiat Isot. 2012 Oct;70(10):2377-83. doi: 10.1016/j.apradiso.2012.07.009. Epub 2012 Jul 17.

DOI:10.1016/j.apradiso.2012.07.009
PMID:22871441
Abstract

A review of the literature pertaining to the production and separation of (67)Cu. This isotope is useful from both therapeutic and diagnostic standpoints due to its medium energy beta particle, gamma emissions, and 2.6-day half-life. It has been produced via proton, neutron, and gamma irradiations on zinc followed by solvent extraction, ion exchange, electrodeposition, and/or sublimation. Widespread use of this isotope for clinical studies and preliminary treatments has been limited by unreliable supplies, cost, and difficulty in obtaining therapeutic quantities.

摘要

一篇关于(67)铜的生产与分离的文献综述。由于其具有中等能量的β粒子、γ射线发射以及2.6天的半衰期,该同位素从治疗和诊断角度来看都很有用。它是通过对锌进行质子、中子和γ辐照,然后经过溶剂萃取、离子交换、电沉积和/或升华而制备出来的。这种同位素在临床研究和初步治疗中的广泛应用受到供应不可靠、成本以及获得治疗剂量困难等因素的限制。

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2
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